SBIR Phase I: New Convergent X-Ray Beam Based System for Protein Crystallography

SBIR 第一阶段：用于蛋白质晶体学的新型会聚 X 射线束系统

• 批准号: 0214720
• 负责人: Huapeng Huang
• 金额: $ 9.99万
• 依托单位: X-RAY OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0214720&HistoricalAwards=false
• 关键词: SBIR; Phase; New; Convergent; Ray

0214720HuangThis Small Business Innovative Research Phase I project proposesto develop a new approach to protein x-ray crystallography using convergent beams. This new technology is based on the development of convergent beam x-ray optics and of protein diffraction theory with 2-dimensional convergent x-ray beams. Compared with conventional collimating optics, convergent beam optics can provide x-ray beams with orders of magnitude higher flux density, which is crucial for structure measurements with small protein crystals (less than 100 um) using low-power laboratory-based x-ray sources. In this Phase I project, simulation diffraction patterns for different protein crystals will be generated by a new software package CBMPRO to theoretically evaluate the feasibility for determination of protein crystal quality, unit cell, space group, and structure.The commercial application of this project is in the area of proteomics.

0214720 HuangThis Small Business Innovative Research Phase I project proposes to develop a new approach to protein x-ray crystallography using convergent beams.这项新技术是基于会聚束X射线光学和蛋白质衍射理论与二维会聚X射线束的发展。与传统的准直光学器件相比，会聚光束光学器件可以提供具有数量级更高通量密度的X射线束，这对于使用低功率实验室X射线源进行小蛋白质晶体（小于100 μ m）的结构测量至关重要。在第一期计划中，我们将利用一个新的软件包CBMPRO生成不同蛋白质晶体的模拟衍射图，从理论上评估蛋白质晶体质量、晶胞、空间群和结构测定的可行性，该计划的商业应用是在蛋白质组学领域。