SBIR Phase I: Novel Microsphere Biomaterials for Genomics and Industry

0214808 Pegg这一小企业创新研究第一阶段项目提出开发一种名为Sphericules的新型生物材料微粒。这些微粒是独立的微米级反应器，能够在没有昂贵仪器的情况下进行遗传分析。新型复合微珠具有温度稳定性、耐溶剂性、可控浮力和其他特性，将在许多不同的市场中找到应用。Sphericule方法结合了天然和合成聚合物、金属、陶瓷和其他化学品的层，以生产新的复合珠、纤维和涂层。 相比之下，在微米尺寸的荧光颗粒上使用抗体的表面涂层的多功能乳胶珠的生产是劳动密集型的。颗粒批量处理导致聚集、不均匀的表面处理和信号分子的损失。这个第一阶段项目提出了一种新的方法，用于在连续过程中使用微尺度系统合成均匀的颗粒。在这个过程中，微珠形成、光学试剂掺入和表面修饰的化学反应预计是直接的、化学计量的和可预测的。该项目的商业应用是在生物医学研究，诊断，电子和国防领域。

0214808PeggThis Small Business Innovation Research Phase I Project proposes to develop novel biomaterial-based microparticles called Sphericules. These microparticles are self-contained micrometer-scale reactors capable of performing genetic analysis without expensive instruments. The new composite beads, with temperature stability, solvent resistance, controlled buoyancy and other properties, will find applications in many diverse markets. The Sphericule methodology combines layers of natural and synthetic polymers, metals, ceramics and other chemicals to produce new composite beads, fibers and coatings. In contrast, multifunctional latex beads using a surface coating of antibody on a micron sized fluorescent particle are labor intensive to produce. Particle batch processing results in aggregation, uneven surface treatment, and loss of signal molecules. This Phase I project proposes a novel method for synthesizing uniform particles using micro-scale systems in a continuous process. In this process, the chemistries of bead formation, optical reagent incorporation and surface modifications are expected to be straightforward, stoichiometric and predictable. The commercial applications of this project are in the areas of biomedicalresearch, diagnostics, electronics, and defense.