MRI/RUI: Acquisition of a 400 MHz FT-NMR Spectrometer

丹尼森大学化学系将从主要研究仪器(MRI)计划获得这一奖项，从而获得一台400 MHz傅立叶变换核磁共振(FT-核磁共振)光谱仪。该设备将使研究人员能够开展以下研究：a)利用耦合自旋弛豫探测大分子中的动力学；b)亚甲基桥位取代杯[4]芳烃的合成和表征；c)质子化环丙烷在萜类重排中的反应性和立体化学研究；以及d)最近邻对多肽化学位移影响的核磁共振研究和化学修饰蛋白质的研究。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。除了涉及本科生的研究外，该仪器还将用于丹尼森大学的一些高级本科实验室课程。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Denison University will acquire a 400 MHz Fourier Transform Nuclear Magnetic Resonance (FT-NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) probing dynamics in macromolecules using coupled spin relaxation; b) synthesis and characterization of methylene bridge substituted calix[4]arenes; c) studies of the reactivity and stereochemistry of protonated cyclopropanes in terpenoid rearrangements; and d) NMR studies of nearest neighbor effects on chemical shifts in peptides and studies of chemically modified proteins. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. In addition to research involving undergraduate students, this instrument will be used in a number of advanced undergraduate laboratory courses at Denison University.