MRI/RUI: Acquisition of a 400 MHz FT-NMR Spectrometer

凭借来自主要研究仪器（MRI）项目的这一奖项，丹尼森大学化学系将获得一台400 MHz傅里叶变换核磁共振（FT-NMR）光谱仪。该设备将使研究人员能够开展以下研究：a)利用耦合自旋弛豫探测大分子动力学；B)亚甲基桥取代杯杯芳烃的合成与表征；C)萜类重排中质子化环丙烷的反应性和立体化学研究；d)核磁共振对肽中化学位移的最近邻效应和化学修饰蛋白质的研究。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。除了涉及本科生的研究外，该仪器还将用于丹尼森大学的一些高级本科生实验课程。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Denison University will acquire a 400 MHz Fourier Transform Nuclear Magnetic Resonance (FT-NMR) Spectrometer. This equipment will enable researchers to carry out studies on a) probing dynamics in macromolecules using coupled spin relaxation; b) synthesis and characterization of methylene bridge substituted calix[4]arenes; c) studies of the reactivity and stereochemistry of protonated cyclopropanes in terpenoid rearrangements; and d) NMR studies of nearest neighbor effects on chemical shifts in peptides and studies of chemically modified proteins. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. In addition to research involving undergraduate students, this instrument will be used in a number of advanced undergraduate laboratory courses at Denison University.