In Vivo Hybridization Chain Reaction: proof of principle Xenograft mouse study to demonstrate a nanotechnology based conditional cancer therapy, selectively killing mutant cells, while leaving healthy cells untouched.
In Vivo Hybridization Chain Reaction: proof of principle Xenograft mouse study to demonstrate a nanotechnology based conditional cancer therapy, selectively killing mutant cells, while leaving healthy cells untouched.
体内杂交链式反应：原理证明异种移植小鼠研究展示了基于纳米技术的条件性癌症疗法，选择性杀死突变细胞，同时不影响健康细胞。
批准号：
158972173
负责人：
Dr. Tobias Heinen
金额：
$0.0万
依托单位国家：
德国
项目类别：
Research Fellowships
财政年份：
2009
资助国家：
德国
项目状态：
已结题
起止时间：
2008-12-31 至 2011-12-31
中文摘要
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英文摘要
In Vivo Hybridization Chain Reaction: triggered therapeutics for targeted destruction of cancer cellsHybridization Chain Reaction (HCR) is a new method in nucleic acid based nanotechnology. Two thermodynamically metastable small conditional RNAs (scRNAs) form a long double-stranded RNA polymer, only if a diagnostic RNA target is present. This method can be adapted to selectively kill cancer cells in vitro while leaving other cells untouched. The current aim is to develop a conditional therapy for the treatment of cancer, which recognizes and selectively destroys tumors. Therefore, scRNAs are to be tested in xenograft mouse models. State of the art nanoparticle RNA-delivery systems are used to deliver scRNAs to tumors in vivo.
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