Thermal Modeling of Head and Neck

拟议的项目是启动一个基本的头部和颈部系统的传热研究，以预测大脑温度。 这项研究将涉及莱斯大学的一项工程研究和德克萨斯大学西南医学中心的一名医学研究人员的合作。 目前有相当多的数据证明需要知道患有缺氧缺血的婴儿的大脑温度，或处于缺氧缺血的巨大风险中。 类似的考虑扩展到其他患者年龄组，包括儿童和成人头部创伤，先天性心脏病的手术矫正，以及成人中风。通过将代谢产热与温度之间的关系、生理参数和调节机制对脑血流的影响以及颈部血管中的逆流传热结合起来，建立了头部和颈部的热模型。 作为A博士的一部分。Laptook正在UTSMC进行的关于新生小型猪脑的研究，将向Y博士提供额外的测量结果。Bayazitoglu在她的头部和颈部的热模型，以确定如何脑温度是由动脉血氧分压，动脉二氧化碳分压，脑代谢率和脑缺血的急性变化的影响，启动的研究将提供重要的未来贡献的基础，在了解脑损伤的发病机制，并在治疗干预过程中监测脑温度。此外，创建的数学模型最终将被用作教学工具，通过将温度作为另一个变量来搜索最佳治疗。

The proposed project is to initiate a fundamental heat transfer study of the head and neck system to predict the brain temperature. The research will involve the collaborative efforts of an engineering research at Rice University and a medical researcher at the University of Texas Southwestern Medical Center. There is considerable data at present to justify the need to know the brain temperature in infants who have suffered hypoxia-ischemia, or are at great risk for hypoxia-ischemia. Similar considerations extend to other patient age groups including children and adults with head trauma, surgical correction of congenital heart disease, and adults with stroke. A thermal model for head and neck will be initiated by incorporating the relation between metabolic heat generation and temperature, the effect of physiological parameters and regulatory mechanisms on the cerebral blood flow and the countercurrent heat transfer in the neck's vessels. As a component of Dr. A. Laptook's ongoing investigations on newborn miniature swine brain at UTSMC, additional measurements will be made available to Dr. Y. Bayazitoglu at Rice to include them in her head and neck thermal modeling, to determine how brain temperature is affected by acute alterations in arterial oxygen tension, arterial carbon dioxide tension, brain metabolic rate, and brain ischemia.The initiated research will provide foundation of important future contributions in understanding the pathogenesis of brain injury, and in monitoring of brain temperature during therapeutic interventions. In addition, the created mathematical models will eventually be used as teaching tools to search for optimal treatment by incorporating temperature as another variable.