Biomimetic Molecular Recognition of Carbohydrates and Peptides (B06)

在这个项目中，我们利用二硫化物的动态共价化学来鉴定碳水化合物的仿生受体。在下一阶段，我们将追求三个相关的目标。首先，我们现在将应用动态共价化学方法来鉴定在水溶液中起作用的小肽的受体。其次，我们将优化脂质体动态糖基化的模型系统。我们的目标是开发可以在几分钟内与任何（简单）碳水化合物糖基化的脂质体，并研究脂质体和凝集素的多价相互作用。最后，基于我们使用自聚集肽的初步结果，我们的目标是探索光化学二硫交换是否可以更广泛地用于动态共价化学，通过照射激活休眠的动态系统。动态化学的光控制具有很高的吸引力，因为它提供了在时间和空间上控制交换反应的机会。

In this project, we have used dynamic covalent chemistry of disulfides to identify biomimetic receptors for carbohydrates. In the next phase, we will pursue three related objectives. First, we will now apply the method of dynamic covalent chemistry to identify receptors for small peptides that operate in aqueous solution. Second, we will optimize our model system for dynamic glycosylation of liposomes. It is our aim to develop liposomes that can be glycosylated within minutes with any (simple) carbohydrate and to investigate the multivalent interaction of the liposomes and lectins. Finally, based on our first results using self-aggregating peptides, it will be our aim to explore if photochemical disulfide exchange can be used more broadly in dynamic covalent chemistry to activate dormant dynamic systems by irradiation. Photocontrol of dynamic chemistry is highly attractive since it offers the opportunity to control the exchange reaction both in time and in space.