CAREER: Creation of Complex Biomimetic Materials via Molecular Recognition

职业：通过分子识别创建复杂的仿生材料

• 批准号: 1332351
• 负责人: Yong Wang
• 金额: $ 39.3万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1332351&HistoricalAwards=false
• 关键词: CAREER; Creation; Complex; Biomimetic; Materials

This Career award by the Biomaterials program in the Division of Materials Research to University of Connecticut aims to create a new generation of tissue-like biomaterials based on novel hydrogels that are functionalized with nucleic acid aptamers for potential use of these hydrogels as synthetic mimics of extracellular matrix. Biomaterials that can recapitulate complex functions of natural tissues will not only provide a deeper insight into biological systems, but also offer a variety of applications such as tissue repair or organ regeneration. The proposed studies include synthesis and characterization of polymers and hydrogels that are functionalized with nucleic acid aptamers; study of the molecular recognition between affinity polymers and their targets at different interfaces; and investigation of the roles of aptamers and molecular triggers in regulating the release of multiple signal molecules from hydrogels. The coordination of numerous signals from the tissue-like biomaterials is expected to determine whether cells undergo proliferation, migration, differentiation, or other critical functions. The educational activities will be pursued to stimulate prospective students' passion and interests in science and engineering; encourage the students of different levels to learn both cutting-edge nanobiotechnology techniques and 21st century skill sets; and enable the broad dissemination of nanobiotechnology knowledge not only to scholars and students in the field, but also to the general public and prospective students.Tissue loss or organ failure is one of the most challenging health problems in the biomedical field. Tissue engineering and regenerative medicine is a promising field that applies the principles of multiple disciplines together towards tissue repair or organ regeneration. However, one of the challenges in this field is the creation of novel materials that are expected to mimic the complex structures and functionality of human tissues. The proposed research is designed to develop tissue-like materials that possess multiple features including communication with human cells. These synthetic polymers with functional groups hold strong potential of stimulating tissue repair or organ regeneration. The educational outreach efforts will be coupled with diverse teaching and outreach activities such as the training of high-school students and teachers, the development and teaching of a new course, and the establishment of a popular science website for the dissemination of nanobiotechnology knowledge. The students of different levels from K-12 to graduate studies will pursue research in an encouraging and collaborative environment, learning cutting-edge nanobiotechnology and other related fields in sciences and engineering.

生物材料计划的材料研究部门的职业奖旨在基于新一代的组织样生物材料基于新一代的基于新型水凝胶的生物材料，这些生物凝胶与核酸适体官能化，以便将这些水凝胶作为外细胞外基质的合成模拟物的合成模拟物。可以概括天然组织复杂功能的生物材料不仅可以更深入地了解生物系统，而且还提供了多种应用，例如组织修复或器官再生。拟议的研究包括与核酸适体功能化的聚合物和水凝胶的合成和表征。研究亲和力聚合物及其靶标之间的分子识别；并研究适体和分子触发器在调节水凝胶中释放多个信号分子的作用。预计来自组织样生物材料的众多信号的协调可以确定细胞是否经历增殖，迁移，分化或其他关键功能。将进行教育活动，以刺激潜在学生对科学和工程的热情和兴趣；鼓励不同级别的学生学习尖端的纳米元素技术技术和21世纪的技能；并使纳米元学知识的广泛传播不仅对该领域的学者和学生，而且还可以向公众和潜在的学生传播。遗传损失或器官衰竭是生物医学领域中最具挑战性的健康问题之一。组织工程和再生医学是一个有前途的领域，将多个学科的原理一起用于组织修复或器官再生。但是，该领域的挑战之一是创建新型材料，这些材料有望模仿人体组织的复杂结构和功能。拟议的研究旨在开发具有多种特征的组织样材料，包括与人类细胞的通信。这些具有官能团的合成聚合物具有刺激组织修复或器官再生的强大潜力。教育宣传工作将与各种各样的教学和推广活动相结合，例如培训高中生和教师，新课程的发展和教学以及建立流行的科学网站，以传播纳米机学技术知识。从K-12到研究生研究的不同级别的学生将在令人鼓舞和协作的环境中进行研究，学习尖端的纳米型技术以及科学和工程学中的其他相关领域。