SGER: Vasotiinergic Mechanisms Associated with the Control of Social Behavior

SGER:与社会行为控制相关的血管能机制

基本信息

  • 批准号:
    0223655
  • 负责人:
  • 金额:
    $ 8.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2002
  • 资助国家:
    美国
  • 起止时间:
    2002-06-01 至 2003-08-31
  • 项目状态:
    已结题

项目摘要

There are two closely related peptide hormones called arginine vasotocin (AVT) and arginine vasopressin (AVP) that have been implicated in several vertebrates as modulators of social behavior, including courtship, pair-bonding, parenting, and aggression. The mechanisms by which these molecules act in the brain to produce these behavioral effects remain unclear, but their widespread distribution suggests they are evolutionarily conserved. It has been suggested that AVT/AVP may affect the processing of species-typical social releasing stimuli such as courtship calls, visual displays, or chemical signals. It is important to take a comparative approach to this question, to determine whether or not AVT/AVP can selectively influence behavioral and brain responses to the specific releasing stimuli that have evolved in different groups of animals for social communication. This project is a Small Grant for Exploratory Research to test this hypothesis directly using goldfish, because the exact chemical stimuli important for courtship and aggressive communication signals in this species are uniquely identified and can be delivered quantitatively. The project is exploratory because it is not yet clear whether AVT will influence social behavior in goldfish, although AVT effects on social behavior have been shown in other teleost fish, and some AVT/AVP effects are known for diverse other vertebrates. Experiments manipulating AVT levels in the brain will measure effects on courtship and aggressive behaviors in male goldfish during responses to particular chemosensory social stimuli that release those behaviors. This is a high-impact/high-risk project because the outcome is not clear, but the potential impact of success is wide-ranging. If successful, the results will lead to further studies on social regulatory functions of hormones, will have an impact beyond behavioral neuroendocrinology to brain neurochemistry, animal behavior, and evolutionary neuroscience, and could have an impact on applications in aquaculture and fisheries industries.
有两种密切相关的肽类激素,称为精氨酸催产素(AVT)和精氨酸加压素(AVP),在几种脊椎动物中作为社会行为的调节剂,包括求爱,配对,养育和侵略。 这些分子在大脑中产生这些行为效应的机制尚不清楚,但它们的广泛分布表明它们在进化上是保守的。 有人认为,AVT/AVP可能会影响处理的物种典型的社会释放刺激,如求偶电话,视觉显示,或化学信号。 重要的是采取比较的方法来解决这个问题,以确定AVT/AVP是否可以选择性地影响行为和大脑对特定的释放刺激的反应,这些刺激已经在不同的动物群体中进化为社会交流。 这个项目是一个探索性研究的小额赠款,直接使用金鱼来测试这一假设,因为在这个物种中对求爱和攻击性通信信号很重要的确切化学刺激是唯一确定的,并且可以定量提供。 该项目是探索性的,因为目前尚不清楚AVT是否会影响金鱼的社会行为,尽管AVT对社会行为的影响已在其他硬骨鱼中显示出来,并且一些AVT/AVP效应已知用于其他脊椎动物。 操纵大脑中AVT水平的实验将测量雄性金鱼对释放这些行为的特定化学感觉社会刺激的反应过程中对求爱和攻击行为的影响。 这是一个高影响/高风险项目,因为结果尚不明确,但成功的潜在影响是广泛的。 如果成功,结果将导致对激素的社会调节功能的进一步研究,将对行为神经内分泌学以外的脑神经化学,动物行为和进化神经科学产生影响,并可能对水产养殖和渔业行业的应用产生影响。

项目成果

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Richmond Thompson其他文献

Why biodiversity matters in the lab
为什么生物多样性在实验室中很重要
  • DOI:
    10.1016/j.yhbeh.2024.105509
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Richmond Thompson;Yvon Delville;Christine Lattin
  • 通讯作者:
    Christine Lattin

Richmond Thompson的其他文献

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{{ truncateString('Richmond Thompson', 18)}}的其他基金

RUI: Non-genomic Androgen Receptor Mechanisms Involved in Social Regulation
RUI:参与社会调节的非基因组雄激素受体机制
  • 批准号:
    2032610
  • 财政年份:
    2020
  • 资助金额:
    $ 8.25万
  • 项目类别:
    Standard Grant
RUI: Non-genomic Androgen Receptor Mechanisms Involved in Social Regulation
RUI:参与社会调节的非基因组雄激素受体机制
  • 批准号:
    1656596
  • 财政年份:
    2017
  • 资助金额:
    $ 8.25万
  • 项目类别:
    Standard Grant
RUI: Rapid Effects of Sex Steroids on Visual Processes Related to Social Communication
RUI:性类固醇对与社交沟通相关的视觉过程的快速影响
  • 批准号:
    0849102
  • 财政年份:
    2009
  • 资助金额:
    $ 8.25万
  • 项目类别:
    Continuing Grant
RUI: Vasotocin Mechanisms Controlling Social Behavior
RUI:控制社会行为的加压素机制
  • 批准号:
    0420938
  • 财政年份:
    2004
  • 资助金额:
    $ 8.25万
  • 项目类别:
    Continuing Grant
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