fMRI of Hormonal Variation in Cognitive-Affective Processing

认知情感处理中荷尔蒙变化的功能磁共振成像

• 批准号: 0224221
• 负责人: Turhan Canli
• 金额: --
• 依托单位: SUNY at Stony Brook
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0224221&HistoricalAwards=false
• 关键词: fMRI; Hormonal; Variation; Cognitive; Affective

With National Science Foundation support, Dr. Canli and colleagues will conduct a three-year investigation into how changes in hormonal state affect brain activation patterns during cognitive and emotion-related psychological processes. Specifically, functional magnetic resonance imaging (fMRI) will be used to record brain activation patterns in response to cognitive and emotional stimuli in two groups of women. One group will consist of women who will be scanned at different times in the naturally occurring menstrual cycle. The other group will consist of post-menopausal women who will be scanned during a three-week period of estrogen/progesterone or placebo (sugar pill) administration. The results of these studies will illuminate our understanding of hormonal regulation of mood and the neural structures that underlie these states. Very little is known about some fundamental aspects of brain function as a function of gender, as suggested by a call by the National Academy of Sciences to devote more biomedical research to sex differences. This work will not only fill a knowledge gap in basic neuroscience, but may also guide future clinical studies to understand the striking sex differences in the incidence of mood disorders such as depression, which strikes as many as four times as many women than men. Furthermore, the proposed work may be of benefit for postmenopausal women weighing the consequences of hormone replacement therapy on brain function. Such decisions will likely be contemplated by large segments of the population, as it is estimated that the average woman will spend at least half her adult life with decreased levels of circulating estrogen.

在美国国家科学基金会的支持下，Canli博士及其同事将进行一项为期三年的研究，研究荷尔蒙状态的变化如何影响认知和情感相关心理过程中的大脑激活模式。具体来说，功能性磁共振成像（fMRI）将用于记录两组女性对认知和情感刺激的大脑激活模式。 一组将由在自然发生的月经周期的不同时间进行扫描的女性组成。 另一组由绝经后妇女组成，她们将在三周的雌激素/孕激素或安慰剂（糖丸）给药期间接受扫描。 这些研究的结果将阐明我们对情绪的激素调节以及这些状态背后的神经结构的理解。 正如美国国家科学院呼吁对性别差异进行更多的生物医学研究所建议的那样，人们对大脑功能作为性别功能的一些基本方面知之甚少。 这项工作不仅将填补基础神经科学的知识空白，而且还可能指导未来的临床研究，以了解抑郁症等情绪障碍发生率的显着性别差异，女性抑郁症的发病率是男性的四倍。 此外，拟议的工作可能有利于绝经后妇女权衡激素替代疗法对脑功能的影响。 这样的决定可能会被大部分人口考虑，因为据估计，平均女性将在循环雌激素水平下降的情况下度过至少一半的成年生活。