Pharmaceutical Sorption to Model Soil Components

药物吸附模拟土壤成分

• 批准号: 0225696
• 负责人: Allison MacKay
• 金额: --
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0225696&HistoricalAwards=false
• 关键词: Pharmaceutical; Sorption; Model; Soil; Components

0225696 MacKay Human and veterinary pharmaceutical compounds are detected increasingly in many environmental media, including soils, sediments, groundwaters and surface waters. It is unknown how humans and organisms will adapt to increasing environmental exposures to these bioactive compounds. Health effects of concern include the spread of antibiotic resistance, endocrine disrupting activity and adverse responses in non-target organisms.Hypothesis and Goal: In addition to interactions with natural organic matter, we hypothesize that pharmaceutical sorption to soils and sediments is governed by 3 mechanisms: (1) electrostatic attraction to oppositely charged sites on mineral surfaces; (2) cation exchange reactions with aluminosilicate clay minerals, and (3) surface complexation to iron and aluminum oxides. The ultimate goal of the proposed research is to quantitatively describe sorption of pharmaceuticals to clay and oxide soil minerals based on a mechanistic understanding of sorption phenomena.Methods: The research goal will be achieved by investigating pharmaceutical sorption to modelsorbents so that with sorbent phases present in real soil or sediment samples can be probedindependently. Five model sorbents will be used: 2- and 3-layer clays (kaolinite and montmorillonite), and iron and aluminum oxides. The high-use veterinary antibiotics oxytetracycline, ciprofloxacin, and FCQA and Enro-CO2 (substructures of ciprofloxacin) will be employed as test sorbates because agricultural antibiotic use represents the most concentrated pharmaceutical release to the environment.Results from this research can be used to predict pharmaceutical sorption from compound properties (solution complexation constant) and sorbent characteristics (surface chemistry at given pH/ionic strength).Significance and Benefits of Research: The proposed research will provide the first mechanistic model of solid-water partitioning of important veterinary antibiotic compounds. The quantitative models developed for high-purity sorbents can be adapted to develop a general partitioning model for any soil or sediment phase. Accurate descriptions of soil- and sediment-water partitioning will help to interpret observed pharmaceutical distributions in field surveys of ambient concentrations of pharmaceutical compounds, including our test sorbates, in surface and groundwater (USGS Toxic Substances Hydrology Program). Ultimately, the quantitative model of pharmaceutical sorption developed here can be used inan environmental fate model that, coupled with a toxicology model, will enable accurate assessments of the risk posed by the release of veterinary pharmaceuticals to aquatic environments.Educational Benefits: Integration of undergraduate students into research activities will provide an opportunity for these students to work closely with faculty to solve open-ended research problems. The proposed research will also form a foundation for future integrated research activities between Environmental, Pharmacy, and Agricultural programs at UConn and Duke.

0225696 麦凯 在许多环境介质中，包括土壤、沉积物、地下沃茨和地表沃茨中，越来越多地检测到人用和兽用药物化合物。目前还不清楚人类和生物体将如何适应这些生物活性化合物日益增加的环境暴露。健康影响的关注包括抗生素耐药性的传播，内分泌干扰活动和不良反应的非目标organis.Hypothesis和目标：除了与天然有机物质的相互作用，我们假设，药物吸附到土壤和沉积物是由3个机制：（1）静电吸引到矿物表面的相反电荷的网站;（2）与铝硅酸盐粘土矿物的阳离子交换反应，和（3）与铁和铝氧化物的表面络合。建议的研究的最终目标是定量描述吸附的药物粘土和氧化物土壤矿物的吸附机理的理解的基础上的吸附phenomenon.Methods：研究目标将通过调查药物吸附modelsorbents，使吸附剂相存在于真实的土壤或沉积物样品可以probedendendently实现。将使用五种模型吸附剂：2层和3层粘土（高岭石和蒙脱石），铁和铝的氧化物。大量使用的兽用抗生素土霉素环丙沙星，以及FCQA和Enro-CO2（环丙沙星的亚结构）将被用作测试吸附剂，因为农业抗生素的使用代表了最集中的药物释放到环境中。（溶液络合常数）和吸附剂特性（在给定pH/离子强度下的表面化学）。研究的意义和益处：该研究将提供重要兽用抗生素化合物的固体-水分配的第一个机理模型。为高纯度吸附剂开发的定量模型可以适用于开发任何土壤或沉积物相的一般分配模型。土壤和沉积物-水分配的准确描述将有助于解释在地表水和地下水中药物化合物（包括我们的试验山梨酸盐）环境浓度的实地调查中观察到的药物分布（USGS有毒物质水文计划）。最终，这里开发的药物吸附定量模型可用于环境归趋模型，再加上毒理学模型，将能够准确评估兽药释放到水生环境中所造成的风险。本科生融入研究活动将为这些学生提供一个机会，与教师密切合作，以解决开放的，结束了研究问题。拟议中的研究也将形成未来的综合研究活动之间的环境，药学和农业计划在康州大学和杜克大学的基础。