Bioorganic Reaction Animations

生物有机反应动画

• 批准号: 0231421
• 负责人: Steven Fleming
• 金额: $ 7.45万
• 依托单位: Brigham Young University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2005-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0231421&HistoricalAwards=false
• 关键词: Bioorganic; Reaction; Animations

Historically the understanding of biological processes has progressed from observation of phenomena at the cellular level to structure determination of biopolymers (i.e. DNA/RNA, proteins and polysaccharides) to elucidation of specific interactions and reactions that govern life processes. As these processes are understood at the molecular and sub-molecular (i.e., functional group) levels, the dependence upon interactions of organic molecules and groups becomes evident. Consequently, information obtained through study of organic reactions and non-covalent interactions among small organic molecules has become directly applicable to the understanding of biological processes. To facilitate students' understanding of how chemical events dictate live processes, three-dimensional interactive animations of reaction pathways for multiple enzymatic processes are being developed based upon enzyme crystal structure and semi-empirical calculations. The software allows students to visualize the chemical events that play a role in these enzyme systems. The goal of this Proof-of-Concept project is to correlate the chemical events in biological processes with those learned in organic chemistry courses.

从历史上看，对生物过程的理解已经从细胞水平的现象观察到生物聚合物(即DNA/RNA、蛋白质和多糖)的结构确定，再到阐明支配生命过程的特定相互作用和反应。随着这些过程在分子和亚分子(即官能团)水平上被理解，对有机分子和基团相互作用的依赖变得明显。因此，通过研究有机小分子之间的有机反应和非共价相互作用而获得的信息已直接适用于理解生物过程。为了帮助学生理解化学事件如何决定生活过程，正在基于酶晶体结构和半经验计算开发多个酶过程的反应路径的三维交互动画。该软件允许学生可视化在这些酶系统中发挥作用的化学事件。这个概念验证项目的目标是将生物过程中的化学事件与在有机化学课程中学到的联系起来。