Acquisition of a New Console for a High Field (600 MHz) NMR Spectrometer

根据化学研究仪器和设施（CRIF）计划的这份合同，爱荷华大学化学系将获得一台用于高场（600 MHz）核磁共振光谱仪的新控制台和探针。该设备将使研究人员能够开展以下研究：a)研究Zn（II）在髓鞘碱性蛋白中的潜在酶促作用，以及设计含有Ca（II）或Ln（III）结合位点的嵌合肽，作为促进水解催化的新型DNA结合基元；B)新的生物活性天然产物的发现、分离和结构测定；C)糖胺聚糖衍生低聚糖的结构测定；d)生物催化和天然抗氧化剂。核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液中分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of Iowa will acquire a new console and probes for a high field (600 MHz) NMR Spectrometer. This equipment will enable researchers to carry out research on a) investigations of the potential enzymatic role of Zn(II) in myelin basic protein and in the design of chimeric peptides containing Ca(II) or Ln(III) binding sites as a novel DNA binding motif to promote hydrolytic catalysis; b) the discovery, isolation and structural determination of new bioactive natural products; c) structure determination of glycosaminoglycan-derived oligosaccharides; and d) biocatalysis and natural antioxidants. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.