MCAA: Role of Metal Ions in the T- to R-Allosteric Transition in the Insulin Hexamer

MCAA：金属离子在胰岛素六聚体 T- 到 R-变构转变中的作用

• 批准号: 0236944
• 负责人: Webe Kadima
• 金额: $ 6万
• 依托单位: SUNY College at Oswego
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-10-01 至 2004-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0236944&HistoricalAwards=false
• 关键词: MCAA; Role; Metal; Ions; Allosteric

This Mid-Career Advancement Award (MCAA) by the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Webe W. Kadima at the State University of New York at Oswego to pursue training in NMR techniques and data analysis methods used for the determination of protein structure. Dr. Kadima will use high field NMR technology to study the role of metal ions, such as Cd(II) and Fe(III), in the T- to R-allosteric transition in the insulin hexamer (R6) in solution.The effects of metal ions on the association and conformational equilibrium of insulin complexes with metal ions will be investigated and the results applied to understanding the behavior of insulin in solution and its regulation and function in vivo. The PI will receive training at nearby institutions in protein structure determination methods, which will be brought to SUNY Oswego to enhance her research involving undergraduates.

该职业中期进步奖（MCAA）由无机、生物无机和有机金属化学项目颁发，支持纽约州立大学奥斯威戈分校的Webe W. Kadima教授进行核磁共振技术和用于测定蛋白质结构的数据分析方法方面的研究。Kadima博士将使用高场核磁共振技术来研究金属离子，如Cd（II）和Fe(III)，在溶液中胰岛素六聚体（R6）的T-到r -变抗转变中的作用。研究金属离子对胰岛素配合物的结合和构象平衡的影响，并将其应用于了解胰岛素在溶液中的行为及其在体内的调节和功能。PI将在附近的机构接受蛋白质结构测定方法的培训，这些方法将被带到纽约州立大学奥斯威戈分校，以加强她对本科生的研究。