PECASE: Investigation of Disease-Resistance Proteins in Flowering Plants

PECASE：开花植物抗病蛋白的研究

• 批准号: 0238311
• 负责人: Kimmen Sjolander
• 金额: --
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0238311&HistoricalAwards=false
• 关键词: PECASE; Investigation; Disease; Resistance; Proteins

Proposal Title: PECASE: Investigation of Disease-Resistance Proteins inFlowering PlantsInstitution: University of California-BerkeleyThe focus of this PECASE award proposal is threefold: (1) teaching and training in computational biology at the undergraduate and graduate levels; (2) continued development of computational methods for problems in molecular biology, and (3) new investigation, using these tools, into disease resistance proteins and pathways, and their effector molecules in bacteria, viruses and fungi. The team will apply new algorithms and software to the analysis and elucidation of key determinants of innate immunity in flowering plants, to predict structure, function, pathway and complex involvement, and so on, for these important protein families. Biologist collaborators will investigate these predictions experimentally, providing critical feedback.Since plants cannot move to escape pathogen attack, they have developed sophisticated strategies and defense mechanisms. Many of these strategies have corollaries in insects and other animals, including human. Because of this, research into plant disease resistance can be expected to produce insights that are relevant not only for genetic engineering of new strains of plants with improved disease resistance (and corresponding increased crop production, and reduction of world hunger), but also to improve our understanding of innate immunity in all eukaryotic organisms, and produce medical and pharmaceutical advances important for human health. The biologists will provide critical feedback, direction, and experimental validation of predictions of protein function and structure. Software and database technologies will be developed to enable the high-throughput classification and inclusion of new plant and pathogen proteins as they are discovered. This synergistic collaboration is designed to combine both hypothesis-driven and hypothesis-generating approaches and the different domain expertise and background knowledge contained in the two groups into a unified understanding of these important protein families and pathways.This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in September 2004.

提案名称：PECASE：开花植物抗病蛋白研究机构：加州大学伯克利分校本次PECASE奖项提案的重点有三个：（1）本科生和研究生水平的计算生物学教学和培训； （2）继续开发分子生物学问题的计算方法，以及（3）利用这些工具对细菌、病毒和真菌中的抗病蛋白和途径及其效应分子进行新的研究。该团队将应用新的算法和软件来分析和阐明开花植物先天免疫的关键决定因素，预测这些重要蛋白质家族的结构、功能、途径和复杂参与等。生物学家合作者将通过实验研究这些预测，提供关键反馈。由于植物无法移动以逃避病原体攻击，因此它们开发了复杂的策略和防御机制。其中许多策略在昆虫和其他动物（包括人类）中都有推论。正因为如此，对植物抗病性的研究有望产生深刻的见解，这些见解不仅与提高抗病性的新植物品种的基因工程相关（以及相应的增加作物产量和减少世界饥饿），而且还有助于提高我们对所有真核生物先天免疫的理解，并产生对人类健康重要的医学和制药进步。生物学家将为蛋白质功能和结构的预测提供关键的反馈、方向和实验验证。将开发软件和数据库技术，以实现对新植物和病原体蛋白的高通量分类和发现。这种协同合作旨在将假设驱动和假设生成方法以及两个小组所包含的不同领域专业知识和背景知识结合起来，形成对这些重要蛋白质家族和通路的统一理解。该项目最初是作为职业奖资助的，并于 2004 年 9 月转变为工程师和科学家总统早期职业奖 (PECASE) 奖。