CAREER: Synthetic and Mechanistic Development of New Desymmetrization

职业：新去对称化的综合和机械发展

• 批准号: 0239527
• 负责人: Satomi Niwayama
• 金额: $ 40万
• 依托单位: Oklahoma State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239527&HistoricalAwards=false
• 关键词: CAREER; Synthetic; Mechanistic; Development; New

The focus of this research is the chiral, non-enzymatic desymmetrization of meso dicarboxylic esters. The methodology, based on the monohydrolysis of symmetrical diesters, results in the production of half acid esters and represents an extremely efficient entry to the preparation of valuable enantiomerically pure starting materials. Enantioselectivity is achieved by the use of quinine-based phase transfer reagents and may be of general utility within the pharmaceutical industry. Dr. Niwayama's educational efforts will focus on the development of a course that interweaves industrial research with traditional academic chemistry.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Satomi S. Niwayama in the Chemistry Department at Oklahoma State University. Professor Niwayama will focus her work on the development of processes that can selectively distinguish between two identical ester groups contained in the same molecule. The process will allow for the preparation of only one of the two possible mirror image products that could result. The methodology is expected to be a very inexpensive way to produce important chemical intermediates used by pharmaceutical companies The educational activities of the award will center on curriculum improvement and will include the development of a new course entitled "Industrial Chemistry."

本研究的重点是手性，非酶催化的内消旋二羧酸酯的去对称化反应。 该方法，对称二酯的单水解的基础上，在生产半酸酯的结果，并代表了一个非常有效的进入到有价值的对映体纯原料的制备。 对映体选择性通过使用基于奎宁的相转移试剂来实现，并且可以在制药工业中具有通用性。 在此期间，Niwayama博士将致力于开发一门将工业研究与传统学术化学相结合的课程。有机与高分子化学项目将通过此次CAREER奖，支持Satomi S.俄克拉荷马州州立大学化学系的Niwayama博士说。 Niwayama教授的工作重点是开发能够选择性区分同一分子中两个相同酯基的方法。这一过程将只允许制备可能产生的两种镜像产物中的一种。 该方法有望成为制药公司生产重要化学中间体的一种非常廉价的方法该奖项的教育活动将集中在课程改进上，并将包括开发一门名为“工业化学”的新课程。"