CAREER: Synthesis of Multi-Functional Mesoporous Silica Materials for Study Intercellular Interaction and Controlled Release Drug Delivery

这项研究的重点是制备无毒的介孔材料，用作传感器或控释药物释放系统。该项目的目标是将多个官能团与结构有序的二氧化硅颗粒结合起来，生产用于检测培养的神经细胞释放的神经递质的“传感纳米球”。不对称的二硫化物将被用来将官能化分子连接到介孔小球的表面。我们将研究这些材料的表面性质，并利用FT-IR、固体核磁共振和荧光光谱来探索它们作为纳米器件控制药物释放的用途。林博士的教育重点将通过这个项目的高度跨学科性质与这些领域内和跨领域的课程发展相结合来提供。凭借这一职业奖，有机和高分子化学项目正在支持爱荷华州立大学化学系的Victor V.Lin博士的研究和教育努力。林教授将专注于使用微小颗粒来感知它们的化学环境，然后通过控制向周围介质释放药物或激素来对不断变化的条件做出反应。预计这些粒子将在拓展神经科学的视野方面发挥作用。该奖项的教育活动将包括向普通化学学生传授材料科学的最新概念。

The focus of this research is to produce non-toxic mesoporous materials for use as sensors or controlled release drug delivery systems. The goal of the project is to use multiple functional groups in conjunction with structurally ordered silica particles to produce "sensing nanospheres" of use in the detection of neurotransmitters released by cultured nerve cells. Unsymmetrical disulfides will be used to attach functionalized molecules to the surface of mesoporous beads. The surface properties of these materials will be studied, and their use as nanodevices for controlled release of encapsulated drugs also will be explored using FT-IR, solid state NMR and fluorescence spectroscopy. Dr. Lin's educational focus will be provided by the highly interdisciplinary nature of this project in conjunction with curricular development within and across these areas. With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Victor V. Lin of the Department of Chemistry at Iowa State University. Professor Lin will focus his work on the use of small particles designed to sense their chemical environment, and then react to changing conditions by the controlled release of drugs or hormones into the surrounding media. It is expected that these particles will be of use in expanding the horizons of neuroscience. The educational activities of the award will include teaching state-of-the-art concepts in material science to general chemistry students.