CAREER: Synthesis of Multi-Functional Mesoporous Silica Materials for Study Intercellular Interaction and Controlled Release Drug Delivery

职业：合成多功能介孔二氧化硅材料，用于研究细胞间相互作用和控释药物输送

• 批准号: 0239570
• 负责人: Victor Lin
• 金额: $ 47万
• 依托单位: Iowa State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239570&HistoricalAwards=false
• 关键词: CAREER; Synthesis; Multi; Functional; Mesoporous

The focus of this research is to produce non-toxic mesoporous materials for use as sensors or controlled release drug delivery systems. The goal of the project is to use multiple functional groups in conjunction with structurally ordered silica particles to produce "sensing nanospheres" of use in the detection of neurotransmitters released by cultured nerve cells. Unsymmetrical disulfides will be used to attach functionalized molecules to the surface of mesoporous beads. The surface properties of these materials will be studied, and their use as nanodevices for controlled release of encapsulated drugs also will be explored using FT-IR, solid state NMR and fluorescence spectroscopy. Dr. Lin's educational focus will be provided by the highly interdisciplinary nature of this project in conjunction with curricular development within and across these areas. With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Victor V. Lin of the Department of Chemistry at Iowa State University. Professor Lin will focus his work on the use of small particles designed to sense their chemical environment, and then react to changing conditions by the controlled release of drugs or hormones into the surrounding media. It is expected that these particles will be of use in expanding the horizons of neuroscience. The educational activities of the award will include teaching state-of-the-art concepts in material science to general chemistry students.

本研究的重点是制备无毒的介孔材料，用作传感器或控释药物传递系统。 该项目的目标是使用多个官能团与结构有序的二氧化硅颗粒结合，生产用于检测培养神经细胞释放的神经递质的“传感纳米球”。 不对称二硫化物将用于将官能化分子连接到介孔珠的表面。 这些材料的表面性质将进行研究，并将使用FT-IR，固态NMR和荧光光谱法探索其作为纳米器件用于胶囊药物的控制释放。 林博士的教育重点将由该项目的高度跨学科性质以及这些领域内和跨领域的课程开发提供。 有了这个职业奖，有机和高分子化学计划是支持州立大学爱荷华州化学系的维克托V.林博士的研究和教育工作。 林教授的工作重点是使用小颗粒来感知其化学环境，然后通过控制药物或激素释放到周围介质中来对变化的条件做出反应。 预计这些粒子将有助于扩大神经科学的视野。 该奖项的教育活动将包括向普通化学学生教授材料科学的最先进概念。