CAREER: An Interdisciplinary Approach Toward Understanding Dynamic Glycosylation in the Brain

职业生涯：理解大脑动态糖基化的跨学科方法

• 批准号: 0239861
• 负责人: Linda Hsieh-Wilson
• 金额: $ 54万
• 依托单位: California Institute of Technology
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0239861&HistoricalAwards=false
• 关键词: CAREER; Interdisciplinary; Approach; Toward; Understanding

This research program focuses on development of an understanding of the role of O-GlcNAc glycosylation in regulating neuronal function and communication, including the regulation of transcription and the control of genes important for learning and memory. The role of O-GlcNAc glycosylation in cyclic AMP response element binding protein-mediated transcription will be explored. Faciliated by development of a synthetic chemical probe enabling the accelerated identification of O-GlcNAc glycosylated proteins on a proteome-wide scale, such modified proteins will be identified in the brain. The educational experience of graduate, undergraduate, and high school students will be enahnced through tailored course discussion and research involvement, and efforts will be made to increase the representation of women in the chemical workforce through provision of support mechanisms and mentorship.With the support of this CAREER Award from the Organic and Macromolecular Chemistry Program and the Molecular and Cellular Biochemistry Program, Professor Linda Hsieh-Wilson, of the Department of Chemistry and Chemical Engineering at the California Institute of Technology, is exploring chemical changes important for brain function and dysfunction. Professor Hsieh-Wilson's studies additionally address the means by which the chemistry of the brain is spatiotemporally regulated to give rise to the intricate biology of the nervous system. These studies are leading to an understanding of the structural, functional, and physiological roles of specific chemical changes in the brain. Professor Hsieh-Wilson is involved in a number of programs designed to enhance the educational experience of graduate, undergraduate, and high school students through tailored course discussion and research involvement and to increase the representation of women in the chemical workforce.

这项研究计划侧重于了解O-GlcNAc糖基化在调节神经元功能和通讯方面的作用，包括转录调节和对学习和记忆重要的基因的控制。将探讨O-GlcNAc糖基化在环状AMP反应元件结合蛋白介导的转录中的作用。通过开发一种能够在蛋白质组范围内加速识别O-GlcNAc糖基化蛋白质的合成化学探针，这种修饰的蛋白质将在大脑中被识别。研究生、本科生和高中生的教育经验将通过量身定制的课程讨论和研究参与得到加强，并将努力通过提供支持机制和指导来增加女性在化学劳动力中的代表性。在有机和高分子化学项目以及分子和细胞生物化学项目的支持下，加州理工学院化学和化学工程系的Linda Hsieh-Wilson教授正在探索对大脑功能和功能障碍具有重要意义的化学变化。谢-威尔逊教授的研究还探讨了大脑的化学物质在时空上受到调节以产生复杂的神经系统生物学的方法。这些研究有助于理解大脑中特定化学变化的结构、功能和生理作用。谢伟信教授参与了一系列项目，旨在通过量身定制的课程讨论和研究参与，提高研究生、本科生和高中生的教育体验，并增加女性在化学劳动力中的代表性。