Development of a Matrix-Assisted Laser Desorption Source for a Fourier-Transform Microwave Spectrometer and the Rotational Spectroscopy of Large Biomolecules

在化学部实验物理化学计划的支持下，图伯根将使用傅里叶变换微波光谱仪来研究溶剂分子对分子构象的影响。PI将为傅里叶变换微波光谱仪开发一种基质辅助激光解吸源。该源将被设计成在不分解的情况下蒸发生物分子。具体地说，他将研究生物分子，包括氨基酸和多肽及其与水的络合物。PI将邀请研究生和本科生参与他的研究。因此，他们将接受当代物理化学前沿领域的培训。该实验室还将开发适用于物理化学教学实验室的新的光谱实验。

In this project supported by the Experimental Physical Chemistry Program of the Chemistry Division, Tubergen will use a Fourier Transform Microwave Spectrometer to study the influence of solvent molecules on molecular conformation. The PI will develop a Matrix-Assisted Laser Desorption source for a Fourier transform microwave spectrometer. The source will be designed to vaporize biomolecules without decomposition. Specifically, biomolecules, including amino acids and peptides and their complexes with water, will be investigated.The PI will engage graduate and undergraduate students in his research. They will thereby receive training in forefront areas of contemporary physical chemistry. The PI will also develop new spectroscopic experiments suitable for a physical chemistry instructional laboratory.