International Research Fellowship Program: Genetic Analysis of Arabidopsis Seed Endosperm Development

国际研究奖学金计划：拟南芥种子胚乳发育的遗传分析

• 批准号: 0301886
• 负责人: Jonathan FitzGerald
• 金额: --
• 依托单位: FitzGerald Jonathan N
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0301886&HistoricalAwards=false
• 关键词: International; Research; Fellowship; Program; Genetic

0301886FitzGeraldThe International Research Fellowship Program enables U.S. scientists and engineers to conduct three to twenty-four months of research abroad. The program's awards provide opportunities for joint research, and the use of unique or complementary facilities, expertise and experimental conditions abroad.This award will support a twenty-four month research fellowship by Dr. Jonathan N. FitzGerald to work with Dr. Frederic Berger at Ecole Normale Superieure de Lyon in Lyon, France.In animals, the pattern of the developing embryo is established by the activity of the Polycomb group (PcG) and Trithorax group (TxG) chromatin remodeling complexes. In Arabidopsis thaliana, the high resolution time-lapse 3D confocal microscopy techniques developed in the host lab enable visualization of PcG action in the developing seed. With this powerful experimental system the host lab is poised for studying gene regulation and patterning by this important class of DNA modifying complexes. The PI plans to isolate and genetically characterize a novel Arabidopsis TxG-like activity, KRONOS, that has been identified in the host lab. Proposed functional studies of KRONOS will further our mechanistic understanding of chromatin regulation during development.

国际研究奖学金计划使美国科学家和工程师能够在国外进行三到二十四个月的研究。该计划的奖项提供了联合研究的机会，并利用国外独特或互补的设施、专业知识和实验条件。该奖项将支持Jonathan N.Fitzgerald博士与法国里昂高等学院的Frederic Berger博士合作24个月的研究奖学金。在动物中，发育中的胚胎模式是通过Polycomb组(PcG)和Trithorax组(TXG)染色质重塑复合体的活动建立的。在拟南芥中，宿主实验室开发的高分辨率延时3D共聚焦显微镜技术使PcG在发育中的种子中的作用得以可视化。有了这个强大的实验系统，宿主实验室就可以研究这类重要的DNA修饰复合体的基因调控和模式。PI计划分离一种新的拟南芥TXG样活性Kronos，并对其进行遗传学表征，该活性已在宿主实验室中确定。提出的对Kronos的功能研究将进一步加深我们对染色质发育过程中染色质调节的机制的理解。