U.S.-Argentina Cooperative Research Program: Transcriptional Regulation of the Sodium Pump

0305484 TowleThis美国-阿根廷奖将支持博士大卫W。托勒，山荒岛实验室（MDIBL）与博士卡洛斯M。该项目将包括对钠泵及其在螃蟹适应盐度变化过程中的作用和调节进行最先进的检查。 他们将研究两种广盐性螃蟹，北大西洋的Carcinus maenas和南美洲的Chasmagnathus granulatus，能够在不同的河口环境中调节血淋巴的渗透浓度的机制。 拟议的研究有机会推进我们对无脊椎动物离子运输控制的理解，并有可能帮助渔业，保护和水产养殖。Towle博士在基因组学和分子生物学方面具有专业知识，而Luquet博士在电生理学和实验生物学方面具有互补的技能。 这种分子和生物/生理方法的结合将为这两个学科带来新的相关性和洞察力。

0305484TowleThis U.S.-Argentina award will support Dr. David W. Towle, Mount Desert Island Laboratory (MDIBL) to work with Dr. Carlos M. Luquet of the University of Buenos Aires in Argentina.This project will consist of a state-of-the-art examination of the sodium pump and its role and regulation during adaptation to salinity change in crabs. They will study the mechanisms by which two species of euryhaline crabs, Carcinus maenas from the North Atlantic and Chasmagnathus granulatus from South America, are able to regulate the osmotic concentration of their hemolymph in a varying estuarine environment. The proposed studies have the opportunity to advance our understanding of the ion transport control in invertebrates with the potential to help fisheries, conservation and aquaculture.Dr. Towle has expertise in genomics and molecular biology, while Dr. Luquet has complementary skills in electrophysiology and experimental biology. This combination of molecular and organismal/physiological approach will bring new relevance and insight into both disciplines.