Postdoctoral Research Fellowship in Interdisciplinary Informatics for FY 2003

2003财年跨学科信息学博士后研究奖学金

• 批准号: 0306035
• 负责人: Matthew Vaughn
• 金额: $ 10万
• 依托单位: Vaughn Matthew W
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0306035&HistoricalAwards=false
• 关键词: Postdoctoral; Research; Fellowship; Interdisciplinary; Informatics

Postdoctoral Research Fellowships in Interdisciplinary Informatics are sponsored jointly by the Directorates for Mathematical and Physical Sciences (MPS) and Biological Sciences (BIO) to encourage research and training that cross the traditional disciplinary boundaries between them. These fellowships provide opportunities for interdisciplinary research and educational activities in biology and informatics to a wide range of recent doctoral recipients (biologists, chemists, physicists, mathematicians, statisticians, computer scientists, and others) who seek to conduct research on biological questions using informatics tools and methods. It is expected that the Fellows trained through these fellowships will play an important role in training the future workforce. Postdoctoral training in informatics will permit junior scientists trained in biology, mathematical, chemical, and physical sciences to play key roles in developing new quantitative tools and methods that will advance informatics in biology and other fields. The title of the fellowship's research and training plan is "Using biological informatics to reveal gene silencing domains in Arabidopsis thaliana." Eukaryotic chromosomes are organized into heterochromatin, which stains intensely in histological preparations and associates with low levels of gene expression, and euchromatin, which stains lightly and contains the majority of active genes. Cryptic, non-staining heterochromatin is thought to be distributed throughout the genome of Arabidopsis thaliana, where it may affect expression of nearby genes. By correlating methylation and gene expression data from genomic microarrays with computationally- and experimentally-derived parameters, this research is identifying new heterochromatic domains and investigating their role in regulating gene expression.

跨学科信息学博士后研究奖学金由数学和物理科学（MPS）和生物科学（BIO）董事会联合赞助，以鼓励跨越传统学科界限的研究和培训。这些奖学金为生物学和信息学的跨学科研究和教育活动提供了机会，以广泛的近期博士学位获得者（生物学家，化学家，物理学家，数学家，统计学家，计算机科学家等），他们寻求使用信息学工具和方法对生物学问题进行研究。 预计通过这些研究金培训的研究员将在培训未来的工作人员方面发挥重要作用。信息学博士后培训将允许接受生物学，数学，化学和物理科学培训的初级科学家在开发新的定量工具和方法方面发挥关键作用，这些工具和方法将推动生物学和其他领域的信息学。 该奖学金的研究和培训计划的标题是“利用生物信息学揭示拟南芥中的基因沉默结构域”。“真核染色体被组织成异染色质和常染色质，异染色质在组织学制备中染色强烈，与低水平的基因表达有关，常染色质染色轻微，含有大多数活性基因。隐藏的非染色异染色质被认为分布在整个拟南芥基因组中，它可能会影响附近基因的表达。通过将来自基因组微阵列的甲基化和基因表达数据与计算和实验得出的参数相关联，这项研究正在识别新的异染色质结构域并研究它们在调节基因表达中的作用。

项目成果

Argonaute slicing is required for heterochromatic silencing and spreading

• DOI: 10.1126/science.1128813
• 发表时间: 2006-08-25
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Irvine, Danielle V.;Zaratiegui, Mikel;Martienssen, Robert A.
• 通讯作者: Martienssen, Robert A.

The B73 Maize Genome: Complexity, Diversity, and Dynamics

• DOI: 10.1126/science.1178534
• 发表时间: 2009-11-20
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Schnable, Patrick S.;Ware, Doreen;Wilson, Richard K.
• 通讯作者: Wilson, Richard K.

Role of transposable elements in heterochromatin and epigenetic control

• DOI: 10.1038/nature02651
• 发表时间: 2004-07-22
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Lippman, Z;Gendrel, AV;Martienssen, R
• 通讯作者: Martienssen, R