Investigation of the Kinetics and Mechanism for Reactions at Thin-Film Surfaces

薄膜表面反应动力学和机理的研究

• 批准号: 0307043
• 负责人: Alice Deckert
• 金额: $ 12.75万
• 依托单位: Allegheny College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0307043&HistoricalAwards=false
• 关键词: Investigation; Kinetics; Mechanism; Reactions; Thin

AbstractCHE-0307043Deckert/Allegheny CollegeThe kinetics of model surface reactions relevant to the adsorption of protein molecules at surfaces are examined in this RUI research project. With the support of the Analytical and Surface Chemistry Program, Professor Deckert and her undergraduate co-workers at Allegheny College examine the kinetics and mechanisms of the adsorption of substituted thiol and amine molecules at self assembled monolayer thin films. Using surface enhanced Raman spectroscopy, attenuated total reflectance infrared spectroscopy, and microbalance measurements, the kinetics of a series of probe reactions are measured. Information from these measurements is then used to develop mechanisms for these adsorption processes. The results of this work are useful for the design of biosensor surfaces. Many strategies have been developed for the attachment of protein molecules to functionalized surfaces. The kinetics of these attachment processes, and their mechanisms, are not well understood. Professor Deckert examines model surface adsorption reactions that mimic the protein adsorption process in order to develop a fuller understanding of these attachment processes. Undergraduate researchers are involved in all aspects of this research.

摘要 CHE-0307043Deckert/阿勒格尼学院 RUI 研究项目研究了与表面蛋白质分子吸附相关的模型表面反应动力学。 在分析和表面化学项目的支持下，Deckert 教授和她在阿勒格尼学院的本科同事研究了自组装单层薄膜上取代硫醇和胺分子吸附的动力学和机制。 使用表面增强拉曼光谱、衰减全反射红外光谱和微量天平测量，测量了一系列探针反应的动力学。 来自这些测量的信息随后被用来开发这些吸附过程的机制。 这项工作的结果对于生物传感器表面的设计很有用。已经开发了许多将蛋白质分子附着到功能化表面的策略。 这些附着过程的动力学及其机制尚不清楚。 Deckert 教授研究了模拟蛋白质吸附过程的表面吸附反应模型，以便更全面地了解这些附着过程。 本科生研究人员参与了这项研究的各个方面。