Catalytic Asymmetric Acyl Halide-Aldehyde Cyclocondensations and Claisen Rearrangements

催化不对称酰卤-醛环缩合和克莱森重排

• 批准号: 0316000
• 负责人: Scott Nelson
• 金额: $ 40万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316000&HistoricalAwards=false
• 关键词: Catalytic; Asymmetric; Acyl; Halide; Aldehyde

The foci of this research involve two areas. First, generally applicable asymmetric acyl halide-aldehyde cyclocondensation variants involving substituted ketene nucleophiles will be developed. Second, diastereoselective and enantioselective variants of Ir(I)-catalyzed Claisen rearrangements will be probed. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott G. Nelson in the Department of Chemistry at the University of Pittsburgh. Professor Nelson will focus his research efforts on developing methodology for the catalytic asymmetric synthesis of useful synthetic intermediates. The research has broader impact for the pharmaceutical industry where the preparation of enantiomerically pure compounds is crucial. Further, the project will provide an excellent arena for the training of graduate students.

本研究的重点涉及两个方面。 首先，将开发涉及取代的烯酮亲核试剂的普遍适用的不对称酰基卤-醛环缩合变体。 第二，非对映选择性和对映选择性的Ir（I）催化克莱森重排的变体将被探测。有了这个奖项，有机和高分子化学计划是支持博士斯科特G。匹兹堡大学化学系的纳尔逊说。 纳尔逊教授将把他的研究重点放在开发有用的合成中间体的催化不对称合成方法上。 该研究对制药行业具有更广泛的影响，其中制备对映体纯化合物至关重要。 此外，该项目将为研究生的培养提供一个极好的竞技场。