Designer Photocatalysts for Asymmetric Photochemistry

用于不对称光化学的设计师光催化剂

• 批准号: 2349003
• 负责人: Tehshik Yoon
• 金额: $ 57.5万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2024
• 资助国家: 美国
• 起止时间: 2024-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2349003&HistoricalAwards=false
• 关键词: Designer; Photocatalysts; Asymmetric; Photochemistry

With the support of the Chemical Synthesis Program in the Division of Chemistry, Professor Tehshik Yoon of the University of Wisconsin–Madison is studying how to use light to improve the discovery and synthesis of structurally complex molecular frameworks, with implications for chemical biology, medicinal chemistry and materials chemistry. In photosynthesis, plants use the energy of light to produce sugars: this is a chemical process that ultimately is responsible for sustaining all life on earth. While chemists have also learned how to use light in chemical synthesis, they have developed no synthetic processes that can achieve the same level of structural complexity and atomic precision as natural photosynthesis. To approach this grand challenge, the Yoon laboratory is designing photocatalysts that can interact directly with small molecules and control how they react to form more complex products. Because this work has the potential to transform discovery in pharmaceutical and materials chemistry, the technical skill sets required to complete this research are in high demand. Thus, one broader impact of this research is the training of a diverse team of young chemists for careers at the cutting edge of the chemical industries. The Yoon group is also leveraging social media tools to present topics in contemporary chemistry to a global community of novice science students who might not otherwise have any exposure to these ideas.Under this award, Professor Tehshik Yoon and his team will design novel photocatalysts take advantage of recent discoveries in solar energy conversion. The team will modify the structures of the most robust and active molecular photocatalysts by introducing polar functional groups that can bind to simple organic substrates through hydrogen-bonding or Lewis acid-base interactions. This enforced proximity is expected to increase the efficiency by which the photocatalyst can influence a chemical reaction. It also provides an opportunity to tune the structure of the photocatalyst to modify the outcomes of the photochemical reaction. Yoon and his team will take an interdisciplinary approach to this research that combines chemical synthesis with computation and spectroscopy to elucidate the detailed mechanisms of photocatalytic reactions. Thus, the outcomes of this research will include both new methods for the synthesis of complex molecular compounds but also fundamental insights into the ways in which light energy can be used in chemical synthesis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学合成计划中的支持下，威斯康星大学 - 麦迪逊分校的Tehshik Yoon教授正在研究如何利用光来改善结构复杂的分子框架的发现和合成，这对化学生物学，医学化学和材料化学具有影响。在光合作用中，植物利用光的能量生产糖：这是一种化学过程，最终负责维持地球上的所有生命。尽管化学家还学会了如何在化学合成中使用光，但他们没有开发出可以达到与自然光合作用相同水平的结构复杂性和原子精度的合成过程。为了应对这一巨大的挑战，Yoon实验室正在设计可以直接与小分子相互作用的光催化剂，并控制它们如何反应形成更复杂的产品。由于这项工作有可能改变药物和材料化学中的发现，因此完成这项研究所需的技术技能集有很高的需求。这项研究的一个更广泛的影响是在化学工业的最前沿培训了一支年轻的化学家团队。 Yoon Group还利用社交媒体工具向全球新颖的科学学生社区展示当代化学的主题，否则他们可能不会对这些想法进行任何接触。在此奖项中，Tehshik Yoon教授和他的团队将设计小说的Photocatlysts，利用太阳能转化中的最新发现。该团队将通过引入可以通过氢键或刘易斯酸基碱相互作用来与简单有机底物结合的极性官能团来修改最健壮和活跃的分子光催化剂的结构。预计这种强制性接近度将提高光催化剂的效率，还提供了调整光催化剂结构以修改光化学反应的结果的机会。 Yoon和他的团队将采用跨学科的方法，将化学合成与计算和光谱法相结合，以阐明光催化反应的详细机制。这是这项研究的结果将包括用于合成复杂分子化合物的新方法，以及对化学合成中的光能使用方式的基本见解。该奖项反映了NSF的法定任务，并被认为是通过评估基金会的知识和更广泛的影响来通过评估的支持来珍贵的，这是珍贵的。