New Cycloaromatization Reactions: Theory and Applications

新环芳构化反应：理论与应用

• 批准号: 0316598
• 负责人: Igor Alabugin
• 金额: $ 34.5万
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316598&HistoricalAwards=false
• 关键词: New; Cycloaromatization; Reactions; Theory; Applications

The focus of this research is in the development of practical applications for novel DNA-cleaving agents, the development of new polymeric materials, and for their organic synthesis. This research provides a theoretical basis for the efficient control of known and design of new cycloaromatization reactions (Bergman cyclizations) proceeding through thermal, photochemical and radical-anionic pathways. The mechanisms of these reactions will be studied experimentally to obtain a better understanding of factors controlling their efficiency, and the findings will be applied to synthesis of substituted triquinanes and new types of well-defined highly-conjugated carbon "ribbons".With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research and educational efforts of Dr. Igor Alabugin of the Department of Chemistry and Biochemistry at the Florida State University, Tallahassee. Professor Alabugin will focus his research on the development of new ways to cleave DNA. This research will contribute to the fundamental understanding of the principles governing the closure of carbon rings using reactive intermediates. Chemistry students at the graduate, undergraduate and post-doctoral level will be trained in Professor Alabugin's laboratory.

本研究的重点是开发新型DNA裂解剂的实际应用，开发新的聚合物材料及其有机合成。 该研究为有效控制已知的和设计新的环芳构化反应（Bergman环化反应）提供了理论基础。 这些反应的机理将进行实验研究，以更好地了解控制其效率的因素，研究结果将应用于合成取代的三醌和新型的定义明确的高度共轭碳“带”。有机和高分子化学计划正在支持化学系的Igor Alabugin博士的研究和教育工作，在塔拉哈西的佛罗里达州立大学学习生物化学。 Alabugin教授将把他的研究重点放在开发切割DNA的新方法上。 本研究将有助于从根本上理解碳环闭合反应的基本原理。 研究生，本科生和博士后水平的化学学生将在Alabugin教授的实验室接受培训。