Modeling the Active Site of Iron Superoxide Dismutase

模拟铁超氧化物歧化酶的活性位点

• 批准号: 0316649
• 负责人: Ferman Chavez
• 金额: $ 1.8万
• 依托单位: Oakland University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316649&HistoricalAwards=false
• 关键词: Modeling; Active; Site; Iron; Superoxide

Ferman Chavez, Department of Chemistry, Oakland University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program for his research program in modeling the active site of iron-dependent superoxide dismutase. The metal-binding site typically contains three nitrogen donors and one oxygen donor derived from the amino acid side chain along with a hydroxide ligand to afford a trigonal bipyramidal geometry. He will design and synthesize organic ligands that mimic this binding site, and then add iron and study the coordination structure and reactivity of the resultant complexes. By studying small molecule models, we can gain insight into metalloenzyme systems.Superoxide dismutase enzymes are ubiquitous in biological systems and protect living systems from the oxidative damage of superoxide by rapidly converting it into oxygen and hydrogen peroxide. Different metals can be involved in this class of enzymes: mammalian enzymes require copper and zinc or manganese while iron-containing superoxide dismutases are found in anaerobic prokaryotes. This award is made under the Minority Research Planning Grant Program and is intended to strengthen the proposal writing and planning capabilities of new investigators and to facilitate preliminary studies and other planning activities related to the research.

奥克兰大学化学系的Ferman Chavez因其对铁依赖性超氧化物歧化酶活性位点建模的研究计划而获得无机，生物无机和有机化学计划的支持。金属结合位点通常含有三个氮供体和一个氧供体，其衍生自氨基酸侧链沿着氢氧化物配体，以提供三角双锥几何结构。 他将设计和合成模拟这种结合位点的有机配体，然后加入铁并研究所得复合物的配位结构和反应性。 通过研究小分子模型，我们可以深入了解金属酶系统。超氧化物歧化酶普遍存在于生物系统中，通过快速将超氧化物转化为氧气和过氧化氢来保护生命系统免受超氧化物的氧化损伤。不同的金属可以参与这类酶：哺乳动物的酶需要铜和锌或锰，而含铁的超氧化物歧化酶在厌氧原核生物中发现。该奖项是在少数民族研究规划补助金计划下颁发的，旨在加强新研究人员的提案撰写和规划能力，并促进与研究相关的初步研究和其他规划活动。