CAREER: Synthesis of Structural and Functional Models for Oxalate Degrading Manganese Enzymes

这项由无机化学、生物无机化学和金属有机化学计划颁发的职业奖支持奥克兰大学的费尔曼·查韦斯教授为草酸盐降解锰酶草酸氧化酶和草酸脱羧酶的活性部位开发小分子模型。我们将详细研究这些模型对草酸盐的反应性。作为拟议研究的结果，他希望有助于阐明这些酶的催化机制，并为小分子提供增强的氧化活性。拟议的教育部分将包括启动一项高中推广方案。与查韦斯教授的研究相关的实验和演示将被开发来向高中生教授基本的化学概念，作为他们课程的一部分。这些活动随后将在密歇根东南部地区的高中教室环境中进行测试。查韦斯教授将举办针对高中化学教师的研讨会，展示新创建的实验和演示。将出版包含这些信息的实验室工作手册和网站。

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry Program supports work by Professor Ferman Chavez at Oakland University to develop small molecule models for the active sites of oxalate degrading manganese enzymes oxalate oxidase and oxalate decarboxylase. The reactivity of these models towards oxalate will be studied in detail. As an outcome of the proposed investigations, he expects to help clarify mechanisms involved in catalysis for these enzymes as well as provide small molecules with enhanced oxidative activity. The proposed educational component will involve the initiation of a high school outreach program. Experiments and demonstrations related to Professor Chavez's research will be developed to teach basic chemistry concepts to high school students as part of their curriculum. These activities will then be tested in high school classrooms settings in the southeastern Michigan area. Professor Chavez will conduct workshops aimed at high school chemistry teachers featuring newly created experiments and demonstrations. A laboratory workbook and website containing this information will be published.