Novel Cyclization Reactions for Organic Synthesis

有机合成的新型环化反应

• 批准号: 0316825
• 负责人: James Takacs
• 金额: $ 42.25万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0316825&HistoricalAwards=false
• 关键词: Novel; Cyclization; Reactions; Organic; Synthesis

The focus of this research involves the development of metal catalyzed bisdiene and enediene carbocyclization reactions for use in total synthesis. The target molecules for the methodology include two dolabellane diterpenes, two indolizidines and the lycopodium alkaloid phegmarine.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. James M. Takacs in the Department of Chemistry at the University of Nebraska-Lincoln. Professor Takacs will focus his research efforts on developing transition metal catalyzed carbocyclization methodology for the synthesis of biologically active molecules. There is potential for broader impact of the work for the pharmaceutical industry and the project presents an excellent arena for the training of undergraduate and graduate students.

这项研究的重点是开发用于全合成的金属催化的双二烯和二烯碳环化反应。该方法的目标分子包括两个Dolabellane二萜、两个Indolizidine和石松碱生物碱Phegmarine。有了这个奖项，有机和高分子化学计划支持内布拉斯加州大学林肯大学化学系的James M.Takacs博士的研究。Takacs教授将致力于开发过渡金属催化的碳环化方法，用于合成生物活性分子。这项工作有可能对制药行业产生更广泛的影响，该项目为本科生和研究生的培训提供了一个极好的舞台。