Catalytic Methods for Asymmetric Synthesis

本研究的重点涉及催化，对映选择性Diels-Alder（DA）化学的发展。 新的金属salen配合物将被合成和杂原子取代的二烯将被开发用于DA反应。 此外，使用氢键而不是刘易斯酸的无金属催化剂将用于促进对映选择性过程。 手性醇和其他氢键供体的不对称催化能力将被检查。 该项目将把晶体学研究和分子建模整合到工作中，以开发模型来合理化观察到的对映体选择性。Rawal在芝加哥大学化学系。 Rawal教授将专注于开发手性化合物的选择性催化制备方法。具体而言，将进行由金属-salen络合物和无金属催化剂催化的对映选择性Diels-Alder（DA）反应。 该领域的工作对制药业产生更广泛影响的潜力很大，该项目也为研究生的培训提供了一个很好的环境。

The focus of this research involves the development of catalytic, enantioselective Diels-Alder (DA) chemistry. New metal-salen complexes will be synthesized and heteroatom-substituted dienes will be developed for use in DA reactions. Further, metal-free catalysts that use hydrogen bonding rather than Lewis acids will be employed to promote the enantioselective process. The asymmetric catalysis capabilities of chiral alcohols and other hydrogen bond donors will be examined. The project will integrate crystallographic studies and molecular modeling into the work in order to develop models to rationalize observed enantioselectivities With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Viresh H. Rawal in the Department of Chemistry at the University of Chicago. Professor Rawal will focus on developing methodology for the selective catalytic preparation of chiral compounds. Specifically, enantioselective Diels-Alder (DA) reactions catalyzed by metal-salen complexes and metal-free catalysts will be carried out. There is great potential for broader impact of the work in the area for the pharmaceutical industry and the project also presents an excellent setting for the training of graduate students.