SBIR Phase I: Novel Nanosized Magnets for Highly Sensitive Multiplexing Bio-Molecular Detection

SBIR 第一阶段：用于高灵敏度多重生物分子检测的新型纳米磁体

• 批准号: 0319333
• 负责人: Ted Sun
• 金额: $ 10万
• 依托单位: LS TECHNOLOGIES
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0319333&HistoricalAwards=false
• 关键词: SBIR; Phase; Novel; Nanosized; Magnets

This Small Business Innovation Research Phase I project is aimed at significantly increasing the signal level or the sensitivity (i.e. by 100~1,000 times) of existing magnetic resonance methods in biomolecule detection and medical imaging, by developing and applying novel contrasting agents or sensor materials based on unique ferromagnetic nanoparticles. Compared to the conventional paramagnetic sensors or contrasting agents used in current magnetic resonance detection methods, the proposed magnetic nanoparticle sensor has a coherent magnetic moment about 1,000 times larger. The nanoparticle sensor is comparable in size to most proteins to minimize the steric hindrance for the binding between cell surface membrane and ligand-attached particles in tagging processes. The unique nanoparticles can be readily prepared in multiplexing forms with distinctively different magnetic resonance signatures for complex bio-molecule tagging and diagnosis applications. Their surfaces can be chemically modified for in-vivo detection of various bio-molecular targets in a cell with high biological specificity. The main commercial application of the this project will be in human healthcare. Products developed from this project will find use as advanced contrasting agents in hospitals for medical diagnosis with MRI (Magnetic Resonance Imaging) and EPRI (Electron Paramagnetic Resonance Imaging). In addition, these products will also find applications in medical research institutes and academic labs for various advanced molecular detection and imaging experiments using NMR (Nuclear Magnetic Resonance) and EPR (Electron Paramagnetic Resonance).

该小型企业创新研究第一阶段项目旨在通过开发和应用基于独特铁磁纳米粒子的新型造影剂或传感器材料，显着提高生物分子检测和医学成像中现有磁共振方法的信号水平或灵敏度（即100~1,000倍）。 与当前磁共振检测方法中使用的传统顺磁传感器或对比剂相比，所提出的磁性纳米颗粒传感器的相干磁矩大约1000倍。 纳米颗粒传感器的尺寸与大多数蛋白质相当，可最大限度地减少标记过程中细胞表面膜与配体附着颗粒之间结合的空间障碍。 这种独特的纳米颗粒可以很容易地以多重形式制备，具有明显不同的磁共振特征，用于复杂的生物分子标记和诊断应用。 它们的表面可以进行化学修饰，以便以高生物特异性对细胞中的各种生物分子靶标进行体内检测。该项目的主要商业应用将是人类医疗保健。该项目开发的产品将在医院中用作先进造影剂，用于 MRI（磁共振成像）和 EPRI（电子顺磁共振成像）的医学诊断。此外，这些产品还将应用于医学研究机构和学术实验室，利用 NMR（核磁共振）和 EPR（电子顺磁共振）进行各种先进的分子检测和成像实验。