SBIR Phase I: Personal Microarray Reader

SBIR 第一阶段：个人微阵列读取器

• 批准号: 0320014
• 负责人: Mark Tondra
• 金额: $ 9.99万
• 依托单位: NVE CORPORATION
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320014&HistoricalAwards=false
• 关键词: SBIR; Phase; Personal; Microarray; Reader

This Small Business Innovation Research (SBIR) Phase I project will develop a magnetic microarray reader that, as part of a magnetics-based bioassay technology, addresses mass consumer applications for microarrays. Magnetic labels as reporters in DNA and immunoassays have already shown excellent sensitivity. Previous versions of magnetic DNA arrays perform DNA and immunoassays directly on the magnetic detector chip surface. A major hurdle for this approach is the intertwining of bioassay surface chemistry and details of magnetic sensor array fabrication. This personal assay reader would permit more rapid breakthroughs in bioassay development by removing this hurdle. This will be accomplished by physically separating the assay chip and the magnetic microarray reader chip. The microarray biochemistry will be performed on a glass slide or whatever surface is best for a given assay. The magnetic microarray reader will be a separate chip with an array of magnetic sensors that physically interlocks with the microarray slide during the assay readout.The commercial application of this project is in the area of microarrays for use in a wide variety of biological and biomedical assays.

这个小企业创新研究（SBIR）第一阶段项目将开发一种磁性微阵列阅读器，作为基于磁性的生物测定技术的一部分，解决了微阵列的大众消费应用。 磁性标记作为DNA和免疫测定中的报告分子已经显示出优异的灵敏度。 先前版本的磁性DNA阵列直接在磁性检测器芯片表面上进行DNA和免疫测定。 这种方法的一个主要障碍是生物测定表面化学和磁传感器阵列制造的细节的交织。 这种个人测定读取器将通过消除这一障碍而允许生物测定开发中的更快突破。 这将通过物理分离测定芯片和磁性微阵列读取器芯片来实现。 微阵列生物化学将在载玻片上或对于给定测定最佳的任何表面上进行。 磁性微阵列阅读器将是一个单独的芯片与磁传感器阵列，物理联锁与微阵列载玻片在测定readia.The商业应用的项目是在微阵列领域的各种生物和生物医学检测。