SBIR Phase I: Personal Microarray Reader

这个小型企业创新研究(SBIR)第一阶段项目将开发一种磁性微阵列读取器，作为基于磁性的生物检测技术的一部分，满足微阵列的大规模消费应用。磁性标记在DNA和免疫分析中作为记者已经显示出极好的灵敏度。以前版本的磁性DNA阵列直接在磁性探测器芯片表面进行DNA和免疫分析。这种方法的一个主要障碍是生物测定、表面化学和磁性传感器阵列制造细节的相互交织。通过消除这一障碍，这种个人化验阅读器将允许在生物化验发展方面取得更多快速突破。这将通过物理分离分析芯片和磁性微阵列读取器芯片来实现。微阵列生物化学将在玻璃片或任何对给定分析最好的表面上进行。磁性微阵列读取器将是一个独立的芯片，带有磁传感器阵列，在检测读出过程中与微阵列载玻片物理上互锁。该项目的商业应用是用于各种生物和生物医学分析的微阵列领域。

This Small Business Innovation Research (SBIR) Phase I project will develop a magnetic microarray reader that, as part of a magnetics-based bioassay technology, addresses mass consumer applications for microarrays. Magnetic labels as reporters in DNA and immunoassays have already shown excellent sensitivity. Previous versions of magnetic DNA arrays perform DNA and immunoassays directly on the magnetic detector chip surface. A major hurdle for this approach is the intertwining of bioassay surface chemistry and details of magnetic sensor array fabrication. This personal assay reader would permit more rapid breakthroughs in bioassay development by removing this hurdle. This will be accomplished by physically separating the assay chip and the magnetic microarray reader chip. The microarray biochemistry will be performed on a glass slide or whatever surface is best for a given assay. The magnetic microarray reader will be a separate chip with an array of magnetic sensors that physically interlocks with the microarray slide during the assay readout.The commercial application of this project is in the area of microarrays for use in a wide variety of biological and biomedical assays.