SBIR Phase I: Bioassay Chip for Massively Parallel Detection of Superparamagnetic Nanospheres using Spin Dependent Tunneling

这个小型企业创新研究第一阶段项目旨在证明在一块芯片上集成大量微流控通道与自旋依赖隧道(SDT)传感器的可行性。这些传感器将检测纳米显微镜超顺磁颗粒的流动，这种颗粒通常用于分离，并在生物检测中用作标记。近期的目标是演示和评估单通道中的粒子检测。最终，这项拟议的工作可能导致具有1000个平行微通道的生物芯片，每个通道都能够以1000/秒的速度检测单个超顺磁性粒子的通过：总检测率为1,000,000个粒子/秒！SDT传感器能够实现如此高的容量，是因为它们可以在亚微米尺寸的元件中制造，与标准硅集成电路集成，并与典型的MEMS和微流体结构相结合。它们是包括各向异性磁阻(AMR)和巨磁电阻(GMR)在内的一类铁磁薄膜材料中最新和最灵敏的传感器。这一新的生物芯片工具可能在检测细胞、蛋白质、生物病原体、液体中的污染物以及进行DNA分析方面具有重要的实用价值。

This Small Business Innovation Research Phase I Project seeks to demonstrate thefeasibility of integrating vast numbers of microfluidic channels with Spin DependentTunneling (SDT) sensors on a chip. These sensors will detect flow of nanoscopicsuperparamagnetic particles of the type typically used for separations and as labels inbioassays. The immediate goal is to demonstrate and evaluate particle detection in singlechannels. Ultimately, the proposed work could lead to a biochip with 1000 parallelmicrochannels, each able to detect the passing of single superparamagnetic particles atthe rate of 1000 / second: a total detection rate of 1,000,000 particles / second! TheSDT sensors enable this high capacity because they can be fabricated in sub-micron sizedelements, integrated with standard silicon integrated circuits, and combined with typicalMEMS and microfluidic structures. They are the latest and most sensitive sensors in theclass of ferromagnetic thin film materials including Anisotropic Magnetoresistance (AMR)and Giant Magnetoresistance (GMR). This new biochip tool may have significant utility for detection of cells, proteins, biological pathogens, pollutants in fluids, and performingDNA analyses.