SBIR Phase I: Bioassay Chip for Massively Parallel Detection of Superparamagnetic Nanospheres using Spin Dependent Tunneling

SBIR 第一阶段：使用自旋相关隧道大规模并行检测超顺磁性纳米球的生物测定芯片

• 批准号: 9961163
• 负责人: Mark Tondra
• 金额: $ 9.98万
• 依托单位: Nonvolatile Electronics Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-01-01 至 2000-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9961163&HistoricalAwards=false
• 关键词: SBIR; Phase; Bioassay; Chip; Massively

This Small Business Innovation Research Phase I Project seeks to demonstrate thefeasibility of integrating vast numbers of microfluidic channels with Spin DependentTunneling (SDT) sensors on a chip. These sensors will detect flow of nanoscopicsuperparamagnetic particles of the type typically used for separations and as labels inbioassays. The immediate goal is to demonstrate and evaluate particle detection in singlechannels. Ultimately, the proposed work could lead to a biochip with 1000 parallelmicrochannels, each able to detect the passing of single superparamagnetic particles atthe rate of 1000 / second: a total detection rate of 1,000,000 particles / second! TheSDT sensors enable this high capacity because they can be fabricated in sub-micron sizedelements, integrated with standard silicon integrated circuits, and combined with typicalMEMS and microfluidic structures. They are the latest and most sensitive sensors in theclass of ferromagnetic thin film materials including Anisotropic Magnetoresistance (AMR)and Giant Magnetoresistance (GMR). This new biochip tool may have significant utility for detection of cells, proteins, biological pathogens, pollutants in fluids, and performingDNA analyses.

这个小型企业创新研究第一阶段项目旨在证明将大量微流体通道与自旋相关隧道（SDT）传感器集成在芯片上的可行性。这些传感器将检测通常用于分离和生物测定中作为标记的纳米级超顺磁性颗粒的流动。当前的目标是演示和评估单通道中的颗粒检测。最终，这项工作可能会产生一种具有1000个平行微通道的生物芯片，每个微通道都能够检测到单个超顺磁性颗粒以每秒1000个的速度通过：总检测速度为每秒100万个颗粒！SDT传感器能够实现这种高容量，因为它们可以在亚微米尺寸的元件中制造，与标准硅集成电路集成，并与典型的MEMS和微流体结构相结合。它们是包括各向异性磁电阻（AMR）和巨磁电阻（GMR）在内的铁磁薄膜材料中最新和最灵敏的传感器。 这种新的生物芯片工具可能对检测细胞、蛋白质、生物病原体、流体中的污染物以及进行DNA分析具有重要的实用性。