MRI/RUI-Acquisition of A High Field NMR for Chemistry Research

MRI/RUI - 获取用于化学研究的高场 NMR

• 批准号: 0320687
• 负责人: Robin Kinnel
• 金额: $ 23.84万
• 依托单位: Hamilton College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0320687&HistoricalAwards=false
• 关键词: MRI; RUI; Acquisition; Field; NMR

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Hamilton College will acquire a 400 MHz NMR Spectrometer. This equipment will enable researchers to carry out research on a) the stereochemistry of bromoallene formation in marine algae; b) investigation of the chemical ecology of asters and the butterflies that use them as host plants; c) isolation and structure of bioactive substances from a sponge; d) a conformational study of synthetic peptides that mimic the minimal active sequence of alpha fetoprotein; e) the development of synthetic methodology and mechanistic studies in free radical chemistry; and f) probing the nature of the nitric oxide oxidation of neurotransmitters. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in marine studies, synthetic organic chemistry and biochemistry.

有了这个奖项从主要研究仪器（MRI）计划，化学系在汉密尔顿学院将获得一个400兆赫核磁共振光谱仪。这一设备将使研究人员能够进行以下研究：（a）海藻中溴丙二烯形成的立体化学;（B）紫菀和以紫菀为寄主植物的蝴蝶的化学生态学研究;（c）从海绵中分离生物活性物质及其结构;（d）模拟甲胎蛋白最低活性序列的合成肽的构象研究; e）发展自由基化学的合成方法和机理研究;和f）探索神经递质的一氧化氮氧化的性质。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。这些核磁共振研究的结果将对海洋研究、合成有机化学和生物化学产生影响。