MRI/RUI: Acquisition of a Transmission Electron Microscope for Multidisciplinary Research and Education

在T. Page Owen博士的指导下，康涅狄格学院获得了一笔赠款，用于购买一台数字透射电子显微镜（TEM），供植物学、化学、心理学和动物学院系使用。TEM将促进细胞科学和材料科学的研究和研究培训活动。与学院的其他科学和数学系一样，生命科学、化学和神经生物学的课程课程致力于为学生提供出色的教育体验，包括多学科研究培训和资助研究机会。科学的总体理念是，本科生的教学和研究是一个统一的活动。他们将满足现场和实际使用现代仪器作为研究工具的巨大需求。获取生物和化学样本的TEM将对教师和学生的生产力和质量产生巨大的智力影响，将来自四个不同部门的教师聚集在一个正在进行和计划中的跨学科研究项目中，包括：(1)植物细胞中高尔基体的组装和活性，(2)不会飞的果蝇的翅膀肌肉组织结构，(3)滞滞后淡水海绵细胞分裂的控制，(4)小鼠星形胶质细胞表达周期蛋白依赖性蛋白激酶的变化，(5)大鼠大脑中神经递质在捕食者气味反应中的免疫定位，(6)具有层状和隧道结构的微孔氧化锰的组织。这些研究计划包括本科生对教师研究的非常有意义的参与。其他的研究项目，通过学生发起的研究，也将使用新的TEM。有了仪器，不同系的教师也可以开始在上层细胞和发育生物学、神经科学、物理、无机和分析化学课程的实验室进行超微结构实验。此外，新型透射电镜的数字成像能力将使细胞和组织超微结构的调查成为可能。通过将TEM引入到课程中，该仪器将对植物学、化学、心理学和动物学教育项目产生广泛的影响，而之前它在这些领域的应用能力有限。在初级到高级的实验室中，通过日常动手操作现代透射电镜仪器所获得的经验，以及与教师的个人研究项目，对学生来说将是无价的，也是培养不同水平的学生从事科学事业的教育过程中至关重要的一部分。

A grant has been awarded to Connecticut College under the direction of Dr. T. Page Owen for the purchase of a digital transmission electron microscope (TEM) to be used by the Departments of Botany, Chemistry, Psychology and Zoology. The TEM will advance research and research training activities in cellular and materials sciences. Along with the rest of the science and math departments at the College, the programmatic offerings of the life sciences, chemistry and neurobiology are dedicated to providing its majors with an outstanding educational experience, including multidisciplinary research training and grant-supported research opportunities. The overarching philosophy in the sciences is that teaching and research with undergraduates is one unified activity.TheTEM will fulfills tremendous need for on-site and hands-on access to modern instrumentation as a research tool. Acquisition of the TEM for biological and chemical samples will have an immense intellectual impact on the productivity and quality of faculty and student experiences, bringing together faculty from four different departments into an interdisciplinary venture in ongoing and planned research projects, including: (1) the assembly and activity of the Golgi apparatus in plant cells, (2) the structure of wing muscle tissue in flightless Drosophila, (3) the control of cell division in freshwater sponges after diapause, (4) the changes in mouse astrocytes expressing a cyclin-dependent protein kinase, (5) the immunolocalization of neurotransmitters in rat brains in response to predator odor, and (6) the organization of microporous manganese oxides with layered and tunneled structures. These research plans incorporate very meaningful participation by undergraduates in faculty research. Additional research projects, through student-initiated research, will also use the new TEM. With the instrument, faculty in the different departments can also begin implementing ultrastructural experiments in laboratories of upper division cell and developmental biology, neuroscience, and physical, inorganic, and analytical chemistry courses. Additionally, thedigitally imaging capabilities of the new TEM will make surveys of cell and tissue ultrastructure possible in introductory courses.This instrument will have a broad impact on the botany, chemistry, psychology,and zoology education programs by introducing TEM into the curriculum, where it waspreviously present in a limited capacity. Experience gained through the routine hands-onoperation of modern TEM instrumentation in beginning- to advanced-level laboratories, in addition to individual research projects with faculty, will be invaluable for the students, and a critically important part of the educational process of preparing students at different levels for careers in science.