Biophotonics: Light Control of Transmembrane Ion Transport in Artificial Membranes

生物光子学：人造膜中跨膜离子传输的光控制

• 批准号: 0322455
• 负责人: Thomas Clausen
• 金额: $ 32.08万
• 依托单位: University of Alaska Fairbanks Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2006-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0322455&HistoricalAwards=false
• 关键词: Biophotonics; Light; Control; Transmembrane; Ion

0322455KhairoutdinovThis project consists of fundamental dynamical studies of artificial closed bilayer membranes containing photochromic ion transporters and ion channels. Its primary purpose is to develop new classes of supramolecular systems that can be reversibly switched by light from electrically conducting to nonconducting states. The design concept is based on the PI recent finding that light illumination could result in the translocation of some photochromic molecules from the membrane interior to the membrane-water interface. Specifically, several types of optically switchable supramolecular ion channels will be constructed and studied that are capable of transmembrane ion transport. They include photosensitive gramicidin A and amphiphilic poly(L-glutamate) containing covalently attached dye molecules and double crowned spiropyran assemblies. Their functioning is based either on photoinduced formation or alteration of the channel conformation or on the light-induced formation of ion-conducting polar sites within the membrane.

0322455Khairoutdinov这个项目包括含有光致变色离子转运体和离子通道的人工闭合双层膜的基础动力学研究。它的主要目的是开发新的超分子系统，这些系统可以用光可逆地从导电状态转换到非导电状态。这个设计概念是基于PI最近的发现，即光照射可以导致一些光致变色分子从膜内部转移到膜-水界面。具体地说，将构建和研究几种类型的光学可切换的超分子离子通道，这些通道能够跨膜离子传输。它们包括光敏性甘草素A和含有共价连接染料分子的两亲性聚(L-谷氨酸)和双冠状螺吡喃组装体。它们的功能要么是基于光诱导的通道构象的形成或改变，要么是基于光诱导的膜内离子传导极性位置的形成。