NTE Phase I (Exploratory): Molecularly Imprinted Conducting Polymer Scaffolds for Sensing and Measurement

NTE 第一阶段（探索性）：用于传感和测量的分子印迹导电聚合物支架

• 批准号: 0329316
• 负责人: S Michael Kilbey
• 金额: $ 9.99万
• 依托单位: Clemson University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-15 至 2006-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0329316&HistoricalAwards=false
• 关键词: NTE; Phase; Exploratory; Molecularly; Imprinted

Kilbey, S. Michael, et al.Clemson University"NTE: Phase I (Exploratory): Molecularly Imprinted Conducting Polymer Scaffolds for Sensing and Measurement"The objective of this exploratory research project is to develop and test a novel method of creating molecularly imprinted polymer layers that are interlaced with conducting polymers for sensing and signaling. The PI's will evaluate the ability of these layers to bind and signal, though changes in electroactivity, the presence of pyrethroids. This class of hazardous insecticide has been selected because of its growing use in urban environments against mosquitoes that carry diseases such as West Nile Virus and because a common structural feature in pyrethroids offers the potential to develop a general (rather than specific) sensor. The molecularly imprinted conducting polymer scaffolds will be created using 3-vinylthiophene. This material allows the growth, via surface confined atom transfer radical polymerization (SC ATRP), the layer in the presence of the template pyrethroid; following layer growth, electrochemical polymerization will be used to couple the thiophene groups throughout the layer. The advantages of this two-step process are distinct: SC ATRP permits controlled growth of the layer, and subsequent electrochemical polymerization crosslinks the scaffold and integrates the conducting polymer throughout the network, thereby providing "on-board" sensing and signaling capabilities. The PI's will use standard spectroscopic techniques to investigate the effect of processing on the layer and a variety of electrochemical techniques to assess the response of the scaffolds to the presence of the target pyrethroids. The PI's will compare the performance of imprinted and non-imprinted materials to evaluate the specificity of the imprinted scaffolds to the target pyrethroids. Broader Impacts:This work will provide a training ground for graduate and undergraduate researchers in areas such as environmental engineering, materials engineering, and nanotechnology. These themes are consistent with employment trends for chemical engineers. Through existing programs at Clemson, opportunities for students from underrepresented groups to participate in this research, which will help ensure that these research activities foster an interdisciplinary training ground. Sensors based on the new scaffolds that will be developed could be used for passive monitoring of pyrethroids in urban areas. Because pyrethroids affect the endocrine and nervous systems, such sensors would allow better monitoring of dispersed dosages and improve the ability of officials to protect citizens. If these novel molecularly-imprinted conducting polymer scaffolds prove to be robust for templating and detecting target molecules, the approach is likely to spur new initiatives to produce sensors with "on-board" signaling capabilities that can be integrated in broader sensor arrays, and expand the applications for electronic noses (impedimetric sensors).

Kilbey, S. Michael 等人克莱姆森大学的“NTE：第一阶段（探索性）：用于传感和测量的分子印迹导电聚合物支架”该探索性研究项目的目的是开发和测试一种创建分子印迹聚合物层的新方法，该分子印迹聚合物层与用于传感和信号传输的导电聚合物交错。 PI 将评估这些层结合和发出信号的能力，尽管电活性的变化、拟除虫菊酯的存在。 之所以选择这类危险杀虫剂，是因为它在城市环境中越来越多地用于对抗携带西尼罗河病毒等疾病的蚊子，并且因为拟除虫菊酯的共同结构特征提供了开发通用（而非特定）传感器的潜力。 分子印迹导电聚合物支架将使用 3-乙烯基噻吩创建。该材料允许通过表面限制原子转移自由基聚合（SC ATRP）在模板拟除虫菊酯存在的情况下生长层；层生长后，将使用电化学聚合来偶联整个层中的噻吩基团。 这种两步过程的优点是明显的：SC ATRP 允许控制层的生长，随后的电化学聚合使支架交联并将导电聚合物集成到整个网络中，从而提供“机载”传感和信号发送功能。 PI 将使用标准光谱技术来研究加工对层的影响，并使用各种电化学技术来评估支架对目标拟除虫菊酯存在的响应。 PI 将比较印迹和非印迹材料的性能，以评估印迹支架对目标拟除虫菊酯的特异性。 更广泛的影响：这项工作将为环境工程、材料工程和纳米技术等领域的研究生和本科生研究人员提供训练场地。这些主题与化学工程师的就业趋势一致。通过克莱姆森大学现有的项目，为来自代表性不足群体的学生提供参与这项研究的机会，这将有助于确保这些研究活动培育跨学科的培训基地。 基于即将开发的新型支架的传感器可用于城市地区拟除虫菊酯的被动监测。由于拟除虫菊酯会影响内分泌和神经系统，因此此类传感器可以更好地监测分散剂量，并提高官员保护公民的能力。 如果这些新型分子印迹导电聚合物支架被证明对于模板化和检测目标分子具有鲁棒性，那么该方法可能会激发新的举措，以生产具有“板载”信号功能的传感器，这些传感器可以集成到更广泛的传感器阵列中，并扩大电子鼻（阻抗传感器）的应用。