Clinical and Microbiological Studies of Faecal Microbiota Transplantation in Ulcerative Colitis - A Phase II, Multicentre, Randomised Double Blind, Exploratory Proof of Concept, Placebo Controlled Trial

粪便微生物群移植治疗溃疡性结肠炎的临床和微生物学研究 - II 期、多中心、随机双盲、探索性概念验证、安慰剂对照试验

• 批准号: nhmrc : 1055871
• 负责人: Dr Sudarshan Paramsothy
• 金额: $ 9.4万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/clinical-microbiological-studies-controlled-trial/112507
• 关键词: Clinical; Microbiological; Studies; Faecal; Microbiota

Ulcerative Colitis (UC) is a chronic inflammatory condition affecting the large bowel. It is the result of a dysfunctional immune system that inappropriately targets and damages the colon. There is increasing evidence that gut bacteria play a crucial role in UC, possibly by stimulating inappropriate activation of immune cells. We believe that by "transplanting" the faeces (and thus gut microbes) of healthy individuals into the colon of UC patients, we may change the bacterial make up and correct the inappropriate immune system activation.

溃疡性结肠炎（UC）是一种影响大肠的慢性炎症。这是免疫系统功能失调的结果，它不适当地针对并损害了结肠。越来越多的证据表明，肠道细菌在UC中起着至关重要的作用，可能是通过刺激免疫细胞的不适当激活。我们认为，通过将健康人的粪便（以及肠道微生物）“移植”到UC患者的结肠中，我们可以改变细菌组成，纠正不适当的免疫系统激活。