SENSORS: Solid-State Imprinted Xerogel Arrays Integrated With Smart CMOS Detectors for Biological Agents

0330240 Titus布法罗大学的多学科研究小组旨在开发新的便携式集成传感器/探测器包。 它涉及以下内容：[1]开发新的超稳定蛋白质印迹干凝胶，选择性地识别给定的蛋白质毒素（例如蓖麻毒素，肉毒杆菌毒素）。[2]生产具有集成发射位点（PIXIES）的蛋白质印迹干凝胶，其在干凝胶内抑制蛋白质毒素的存在。[3]使用基于PIXIES的传感器构建用于同时检测多种毒素的传感器阵列，其中干凝胶直接写入基于III-N的固态发光二极管（LED）的低密度、大器件面积、可寻址阵列上[4]开发硅互补金属氧化物半导体（CMOS）智能检测器阵列，并生产完全集成的基于CMOS智能阵列的器件，其将是电池供电的、重量轻的、此外，每个组件（PIXIE阵列、LED阵列和CMOS探测器阵列）的开发都了解它将如何与其他组件相互作用，从而确保整个传感器系统以最佳方式运行，这一事实增强了研究。这项工作的更广泛影响范围从跨学科培训到开发毒素传感器的社会效益。 研究生和本科生将密切参与拟议工作的各个方面（从实验设计到数据和结果分析，再到制作和提交手稿，以便在科学文献中发表，并在科学会议上提供专业讲座）。学生将获得最先进的仪器，激光，诊断工具，光谱化学分析，检测器设计，电子学，包装、生物分析、合成、材料化学和加工以及化学仪器设计、开发和测试。这种全面的学生培训水平将是进一步学习的跳板（本科生）或作为进入学术界，工业界或政府机构（研究生）具有挑战性和令人满意的职业生涯的跳跃点。将从事拟议研究的学生中有很大一部分将来自代表性不足的群体（女性）。 整个研究工作是多学科的。 这项工作的所有关键成果将通过发表在同行评审的科学文献中广泛传播。学生将充分参与起草和提交所有手稿，以便在同行评审的期刊上发表。学生同事也将准备并在全国会议上介绍他们的工作。

0330240TitusThe multidisciplinary research team at the University at Buffalo aims to develop new, portable integrated sensor/detector packages. It involves the following:[1] Develop new ultrastable protein imprinted xerogels that selectively recognize a given proteinaceous toxin, (e.g. Ricin, Botulinum toxin).[2] Produce protein imprinted xerogels with integrated emission sites (PIXIES) that transduce the proteinaceous toxin's presence within the xerogel.[3] Use the PIXIES-based sensors to construct sensor arrays for simultaneous multi-toxin detection in which the xerogels are directly written on low density, large device area, addressable arrays of III-N based solid state light emitting diodes (LEDs)[4] Develop silicon complementary metal oxide semiconductor (CMOS) smart detector arrays and produce fully integrated CMOS smart array-based devices that will be battery powered, light weight, robust, fast and small.Furthermore, the research is enhanced by the fact that each component (PIXIE array, LED array, and CMOS detector array) is being developed with an understanding of how it will interact with the other components, thus ensuring that the entire sensor system operates optimally. The broader impacts of this work range from interdisciplinary training to societal benefits of developing sensors for toxins. Graduate and undergraduate students will be intimately involved in all aspects of the proposed work (from experiment design to the analysis of data and results to the crafting and submission of manuscripts for publication in the scientific literature and delivering professional lectures at scientific meetings).Students will gain training in state-of-the-art instrumentation, lasers, diagnostic tools, spectrochemical analysis, detector design, electronics, packaging, bioanalysis, synthesis, materials chemistry and processing, and chemical instrumentation design, development, and testing. This comprehensive level of student training will be a springboard for further studies (undergraduate students) or serve as the jump point into challenging and satisfying careers in academia, industry, or government installations (graduate students).A significant fraction of the students that will be working on the proposed research will be from under- represented groups (female). The entire research effort is multidisciplinary. All key results from this work will be widely disseminated by publication in the peer-reviewed scientific literature.Students will participate fully in the drafting and submission of all manuscripts for publication in peer-reviewed journals. Student co-workers will also prepare for and present their work at national meetings.