MR-PET für Medizinische Bildgebung

多模态成像结合了结构、功能和生物信息，用于疾病的非侵入性表征。与现有方法相比，这种混合全身MR-PET仪器的DFG应用将解决这种新成像方法的方法学和临床验证。据推测，通过提供更好的软组织对比，MR-PET将优于PET/CT在许多类型癌症的诊断和分期方面。此外，MR不仅可以提供高分辨率的结构成像，还可以测量生理和生化组织功能，补充PET的分子信号，用于疾病表型分析。为了开发MR-PET的潜力，一个由慕尼黑两所大学（TUM / LMU）组成的跨学科研究联盟慕尼黑HYCON将进行方法和临床研究，重点是肿瘤学和心脏病学的全身成像。两所大学的物理学家、生物学家和医生在成像领域的合作是基于已建立的临床前（SFB 824， MOBITUM）和临床研究网络，为拟议的研究提供必要的基础设施。

Multimodality imaging combines structural, functional, and biologic information for the noninvasive characterization of diseases. This DFG application for a hybrid whole-body MR-PET instrumentation will address the methodological as well as clinical validation of this new imaging approach in comparison to existing modalities. It is hypothesized, that MR-PET will be superior to PET/CT in the diagnosis and staging of many types of cancer by providing better soft tissue contrast. In addition, MR offers not only high resolution structural imaging, but also measurements of physiological and biochemical tissue function complementing molecular signals by PET for phenotyping of disease. In order to exploit the promising potential of MR-PET, an interdisciplinary research consortium involving both universities in Munich (TUM / LMU), called Munich HYCON, will perform methodological and clinical research focussing on whole body imaging in oncology and cardiology. The cooperation of physicists, biologists and physicians of both universities in the area of imaging is based on an established preclinical (SFB 824, MOBITUM) and clinical research network providing the necessary infrastructure for the proposed research.