Upgrade of 300 and 400 MHz NMR Instruments

有了化学研究仪器和设施(CRIF)计划的这一奖项，约翰霍普金斯大学化学系将升级他们的300 MHz和400 MHz核磁共振谱仪。该设备将使研究人员能够开展以下方面的研究：a)酶模型络合物和新的卟啉系统；b)寡核苷酸生物结合物的合成；c)金属酶活性中心和环境无机化学的生物无机模拟；d)无机配位化合物的光化学；e)合成有机化学；f)有机中间体的结构和反应活性。核磁共振波谱是化学家用来阐明分子结构的最有力的工具之一。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对合成有机化学和生物化学产生影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at Johns Hopkins University will upgrade their 300 MHz and 400 MHz NMR Spectrometers. This equipment will enable researchers to carry out studies on a) enzyme model complexes and new porphyrinoid systems; b) synthesis of oligonucleotide bioconjugates; c) bioinorganic modeling of metalloenzyme active sites and environmental inorganic chemistry; d) photochemistry of inorganic coordination compounds; e) synthetic organic chemistry; and f) structure and reactivity of organic intermediates. Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in synthetic organic chemistry and biochemistry.