Evolvability and Constraint in Fly Wings

飞翼的进化性和约束

• 批准号: 0344417
• 负责人: Thomas Hansen
• 金额: --
• 依托单位: Florida State University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-01 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0344417&HistoricalAwards=false
• 关键词: Evolvability; Constraint; Fly; Wings

This project uses Drosophila melanogaster (fruit flies) to investigate how genes interact with one another. Flies will be selectively bred to change specific aspects of the shape of their wings then studied to reveal how the genes responsible for wing shape interact. First, selection to change some wing aspects while constraining others will be conducted. Comparing the constrained and non-constrained populations will allow estimation of genetic pleiotropy (when single genes influence several traits). Second, experiments will transplant genes between fly populations with different wing shapes. Comparing the effects of these transplants will allow us to estimate the genetic epistasis (how the effects of a particular gene depend on other genes present). Finally, the project tests and investigates a new mathematical model of epistasis and it's implications for evolutionary biology.While pleiotropy and epistasis are known to be common, their properties are poorly understood. These experiments will be among the first to carefully investigate the nature and magnitude of these genetic factors. Understanding these factors has the potential to greatly impact all fields studying genetic interactions, including medicine and livestock breeding. The data will be gathered largely by undergraduate students from the ethnically and economically diverse population of Florida State University.

该项目使用果蝇（果蝇）来研究基因如何相互作用。苍蝇将被选择性地培育，以改变翅膀形状的特定方面，然后研究揭示负责翅膀形状的基因如何相互作用。首先，选择改变一些机翼方面，同时限制其他人将进行。比较约束和非约束群体将允许估计遗传多效性（当单个基因影响几个性状时）。第二，实验将在不同翅膀形状的苍蝇种群之间移植基因。比较这些移植的效果将使我们能够估计遗传上位性（一个特定基因的效果如何取决于其他基因）。最后，该项目测试和研究了一个新的上位性数学模型及其对进化生物学的影响。虽然多效性和上位性是常见的，但它们的性质却知之甚少。这些实验将是第一批仔细研究这些遗传因素的性质和程度的实验。了解这些因素有可能极大地影响所有研究遗传相互作用的领域，包括医学和畜牧业。这些数据将主要由来自佛罗里达州立大学种族和经济多元化人口的本科生收集。