Evolvability and Constraint in Fly Wings

飞翼的进化性和约束

基本信息

  • 批准号:
    0344417
  • 负责人:
  • 金额:
    --
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2004
  • 资助国家:
    美国
  • 起止时间:
    2004-02-01 至 2009-01-31
  • 项目状态:
    已结题

项目摘要

This project uses Drosophila melanogaster (fruit flies) to investigate how genes interact with one another. Flies will be selectively bred to change specific aspects of the shape of their wings then studied to reveal how the genes responsible for wing shape interact. First, selection to change some wing aspects while constraining others will be conducted. Comparing the constrained and non-constrained populations will allow estimation of genetic pleiotropy (when single genes influence several traits). Second, experiments will transplant genes between fly populations with different wing shapes. Comparing the effects of these transplants will allow us to estimate the genetic epistasis (how the effects of a particular gene depend on other genes present). Finally, the project tests and investigates a new mathematical model of epistasis and it's implications for evolutionary biology.While pleiotropy and epistasis are known to be common, their properties are poorly understood. These experiments will be among the first to carefully investigate the nature and magnitude of these genetic factors. Understanding these factors has the potential to greatly impact all fields studying genetic interactions, including medicine and livestock breeding. The data will be gathered largely by undergraduate students from the ethnically and economically diverse population of Florida State University.
该项目使用果蝇(果蝇)来研究基因如何相互作用。苍蝇将被选择性地培育,以改变翅膀形状的特定方面,然后研究揭示负责翅膀形状的基因如何相互作用。首先,选择改变一些机翼方面,同时限制其他人将进行。比较约束和非约束群体将允许估计遗传多效性(当单个基因影响几个性状时)。第二,实验将在不同翅膀形状的苍蝇种群之间移植基因。比较这些移植的效果将使我们能够估计遗传上位性(一个特定基因的效果如何取决于其他基因)。最后,该项目测试和研究了一个新的上位性数学模型及其对进化生物学的影响。虽然多效性和上位性是常见的,但它们的性质却知之甚少。这些实验将是第一批仔细研究这些遗传因素的性质和程度的实验。了解这些因素有可能极大地影响所有研究遗传相互作用的领域,包括医学和畜牧业。这些数据将主要由来自佛罗里达州立大学种族和经济多元化人口的本科生收集。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Thomas Hansen其他文献

The double-edged sword of becoming a caregiver: dynamic impact on four dimensions of well-being in Norway
成为看护者的双刃剑:对挪威福祉四个维度的动态影响
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    3.6
  • 作者:
    F. Methi;R. B. Nes;V. Skirbekk;Thomas Hansen
  • 通讯作者:
    Thomas Hansen
V2X Sidelink Positioning in FR1: From Ray-Tracing and Channel Estimation to Bayesian Tracking
FR1 中的 V2X 侧链定位:从光线追踪和信道估计到贝叶斯跟踪
  • DOI:
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yu Ge;Maximilian Stark;M. F. Keskin;Hui Chen;Guillaume Jornod;Thomas Hansen;Frank Hofmann;Henk Wymeersch
  • 通讯作者:
    Henk Wymeersch
Stereoselective Glycosylations – Additions to Oxocarbenium Ions
立体选择性糖基化 - 加成氧碳鎓离子
  • DOI:
  • 发表时间:
    2017
  • 期刊:
  • 影响因子:
    0
  • 作者:
    B. Hagen;S. V. D. Vorm;Thomas Hansen;G. A. Marel;J. Codée
  • 通讯作者:
    J. Codée
Field Evaluation of a Single-Word Pronunciation Training System
单词发音训练系统的现场评估
Evidence for a possible association of neurotrophin receptor (<em>NTRK-3</em>) gene polymorphisms with hippocampal function and schizophrenia
  • DOI:
    10.1016/j.nbd.2009.03.011
  • 发表时间:
    2009-06-01
  • 期刊:
  • 影响因子:
  • 作者:
    Mona K. Otnæss;Srdjan Djurovic;Lars M. Rimol;Bettina Kulle;Anna K. Kähler;Erik G. Jönsson;Ingrid Agartz;Kjetil Sundet;Håkan Hall;Sally Timm;Thomas Hansen;Joseph H. Callicott;Ingrid Melle;Thomas Werge;Ole A. Andreassen
  • 通讯作者:
    Ole A. Andreassen

Thomas Hansen的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Thomas Hansen', 18)}}的其他基金

Doctoral Dissertation Research: Does language affect cultural identity among minority populations?
博士论文研究:语言会影响少数民族的文化认同吗?
  • 批准号:
    2241654
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Legal and Moral Sources of Trust in the Social Lives of Displaced People
博士论文研究:流离失所者社会生活中信任的法律和道德来源
  • 批准号:
    1728090
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Factors Influencing the Property Claims and the Reorganization of Urban Space
博士论文研究:产权主张影响因素与城市空间重组
  • 批准号:
    1728635
  • 财政年份:
    2017
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Doctoral Dissertation Research: Informality and Flexibility in Loan Networks and Debt Dispute Resolution
博士论文研究:贷款网络和债务纠纷解决的非正式性和灵活性
  • 批准号:
    1458286
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Collaborative Research: Testing Measures of Evolvability: Adaptation and Genetic Constraints in Dalechampia Vines (Euphorbiaceae)
合作研究:测试进化性的测量:Dalechampia 藤蔓(大戟科)的适应和遗传约束
  • 批准号:
    0444157
  • 财政年份:
    2005
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant

相似海外基金

CRII: AF: Streaming Approximability of Maximum Directed Cut and other Constraint Satisfaction Problems
CRII:AF:最大定向切割和其他约束满足问题的流近似性
  • 批准号:
    2348475
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Promise Constraint Satisfaction Problem: Structure and Complexity
承诺约束满足问题:结构和复杂性
  • 批准号:
    EP/X033201/1
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Fellowship
AF:Small: Bayesian Estimation and Constraint Satisfaction
AF:Small:贝叶斯估计和约束满足
  • 批准号:
    2342192
  • 财政年份:
    2024
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Speeding-up SAT-based Constraint Optimization Solvers
加速基于 SAT 的约束优化求解器
  • 批准号:
    23K11047
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Hierarchical Geometric Accelerated Optimization, Collision-based Constraint Satisfaction, and Sensitivity Analysis for VLSI Chip Design
VLSI 芯片设计的分层几何加速优化、基于碰撞的约束满足和灵敏度分析
  • 批准号:
    2307801
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
CAREER: NeuralSAT: A Constraint-Solving Framework for Verifying Deep Neural Networks
职业:NeuralSAT:用于验证深度神经网络的约束求解框架
  • 批准号:
    2238133
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Continuing Grant
CAREER: Toward Real-Time, Constraint-Aware Control of Complex Dynamical Systems: from Theory and Algorithms to Software Tools
职业:实现复杂动力系统的实时、约束感知控制:从理论和算法到软件工具
  • 批准号:
    2238424
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Standard Grant
Illuminating the distribution of extreme evolutionary constraint in the human genome from fetal demise to severe developmental disorders
阐明人类基因组中从胎儿死亡到严重发育障碍的极端进化限制的分布
  • 批准号:
    10601318
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
Evaluating the relative contribution of historical constraint in the evolution of migratory routes of Japanese birds
评估历史约束对日本鸟类迁徙路线演变的相对贡献
  • 批准号:
    23K14272
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Characterization and clinical trial of a Variable Friction Shoe, a new paradigm of reduced-constraint locomotor therapy for people exhibiting foot drop due to stroke
可变摩擦鞋的表征和临床试验,这是一种针对因中风而出现足下垂的患者的减少约束运动疗法的新范例
  • 批准号:
    10720578
  • 财政年份:
    2023
  • 资助金额:
    --
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了