CAREER: Synthesis and Characterization of Metal-Containing PNA

职业：含金属 PNA 的合成和表征

• 批准号: 0347140
• 负责人: Catalina Achim
• 金额: $ 51万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0347140&HistoricalAwards=false
• 关键词: CAREER; Synthesis; Characterization; Metal; Containing

This CAREER award by the Inorganic, Bioinorganic and Organometallic Chemistry program is to support Professor Catalina Achim at Carnegie-Mellon University to create supramolecules that contain transition metal ions and are based on peptide nucleic acids (PNAs), which are synthetic analogues of DNA. Ligand substitution of nucleobases in PNA duplexes confer affinity for metal ions and direct the metal ion binding to predetermined positions in these duplexes. The proposed research involves the synthesis of new PNA monomers that contain ligands, preparation of the PNA oligomers and duplexes, and the characterization of the metal-PNAs by spectroscopic methods. The primary goals of the research is to delineate the factors that influence the formation and stability of PNA structures in which the transition metal ions are incorporated. Information obtained from these studies will be used to achieve the long-term goal of rational design of metal-based devices for molecular electronics. The proposed research is developed at the interface between bio-organic and -inorganic chemistry and offers students a unique opportunity to garner a wide perspective of chemistry. New interdisciplinary courses that bridge this field with Supramolecular Chemistry and with Art will also be developed. A project-oriented approach will be used as pedagogic tool in these courses and some of the projects created by the students will be used to disseminate chemical science to the general public.

这项由无机化学、生物无机化学和金属有机化学项目颁发的职业奖项是为了支持卡内基梅隆大学的Catalina Achim教授创造包含过渡金属离子的超分子，并以多肽核酸(PNA)为基础，PNA是DNA的合成类似物。PNA双链中碱基的配体取代赋予了金属离子的亲和力，并将金属离子结合到这些双链中的预定位置。这项研究包括合成新的含配体的PNA单体，制备PNA齐聚物和双链，以及用光谱方法对金属-PNA进行表征。这项研究的主要目的是描述影响过渡金属离子掺杂的PNA结构形成和稳定性的因素。从这些研究中获得的信息将被用于实现合理设计用于分子电子学的金属基器件的长期目标。建议的研究是在生物有机化学和无机化学的交界处进行的，为学生提供了一个获得广阔化学前景的独特机会。还将开发新的跨学科课程，将这一领域与超分子化学和艺术联系起来。在这些课程中将使用以项目为导向的方法作为教学工具，学生创建的一些项目将用于向公众传播化学科学。