Metal-Containing Peptide Nucleic Acids

含金属肽核酸

• 批准号: 0848725
• 负责人: Catalina Achim
• 金额: $ 36万
• 依托单位: Carnegie-Mellon University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0848725&HistoricalAwards=false
• 关键词: Metal; Containing; Peptide; Nucleic; Acids

This Research award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports work by Professor Achim at Carnegie Mellon University to synthesize hybrid inorganic-peptide nucleic acid (PNA) structures. PNA is a synthetic analogue of DNA that has a pseudo-peptide backbone to which nucleobases are attached. The comparative study of the structure and thermodynamics of formation of non-modified and ligand-modified PNA duplexes, in the absence and presence of metal ions is used to create metal-containing PNAs capable of undergoing structural changes in response to external stimuli. This research developed at the interface between bio-organic and -inorganic chemistry offers to undergraduate and graduate students a unique opportunity to learn about both research fields. The students in the Achim group interact with research groups in the Center for Nucleic Acids Science and Technology at Carnegie Mellon, which exposes them to a broad range of tools for the synthesis and characterization of nucleic acids and gives them a wide perspective of chemistry. The hybrid inorganic-PNA structures synthesized have relevance and potential applications in nanotechnology and molecular electronics.

这个无机、生物无机和有机金属化学项目的研究奖支持卡耐基梅隆大学的Achim教授合成无机肽核酸（PNA）混合结构的工作。PNA是DNA的合成类似物，具有核碱基连接的伪肽主干。在不存在金属离子和不存在金属离子的情况下，对未修饰和配体修饰的PNA双链的结构和形成热力学进行比较研究，用于创建能够响应外部刺激而发生结构变化的含金属PNAs。这项研究是在生物有机化学和无机化学之间的界面上发展起来的，为本科生和研究生提供了一个学习这两个研究领域的独特机会。Achim小组的学生与卡耐基梅隆大学核酸科学与技术中心的研究小组进行互动，这使他们接触到广泛的核酸合成和表征工具，并为他们提供了广泛的化学视角。合成的无机- pna杂化结构在纳米技术和分子电子学方面具有重要的应用前景。