SGER: Template-Controlled Living Polymerization for Synthesis of Self-Assembling Polymers

SGER：用于合成自组装聚合物的模板控制活性聚合

• 批准号: 0352812
• 负责人: Youqing Shen
• 金额: $ 9.98万
• 依托单位: University of Wyoming
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-10-15 至 2006-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0352812&HistoricalAwards=false
• 关键词: SGER; Template; Controlled; Living; Polymerization

Youqing ShenUniversity of Wyoming "SGER: Template-Controlled Living Polymerization for Synthesis of Self-Assembling Polymers."Association of polymer chains with uncontrolled distribution of hydrogen bonding sites leads to random clusters and three-dimensional networks through a process of random intra- and intermolecular bonding which leads to self- and cross-association or both. By contrast, uniform polymer chains (same structure and length from molecule to molecule) with a well-defined distribution of hydrogen-bonding sites can self assemble with their complementary chains, that is, they can form highly aligned chain duplexes with well-defined bond sequences. Such polymer self-assembly, reminiscent of DNA self-assembly, can lead to valuable biotic and abiotic materials. The challenge is how to synthesize such self-assembling polymers.The principal investigator proposes a template-controlled living polymerization for the synthesis of self-assembling polymers. The goal of the exploratory research is to demonstrate that the proposed template-controlled living polymerization is viable, i.e. the monomers can be kept on the template during the polymerization and the polymerization can be kept along the template. Specific objectives of the proposed research are as follows:1) To synthesize template and monomers.2) To develop a living polymerization process for these monomers.3) To develop a template-controlled living polymerization process.This research will clarify the two main concerns to the template-controlled living polymerization. The interdisciplinary research, combining the elements of polymer science, supramolecular chemistry, biochemistry, thermodynamics and materials engineering, will enhance our fundamental understanding to which extent macromolecules must be uniform in order to self assemble, as opposed to randomly self associate. Such understanding will be the basis for future research on polymer self-assembly. In addition to building a knowledge base and seeding future research, the proposed project could result in novel functional materials, such as new silk-like materials having exceptional mechanical and thermal properties.

沉友清怀俄明大学“SGER：用于合成自组装聚合物的模板控制活性聚合。”氢键位点分布不受控制的聚合物链的缔合通过随机分子内和分子间键合过程产生随机簇和三维网络，从而导致自缔合和交叉缔合或两者兼而有之。相比之下，具有明确的氢键位点分布的均匀聚合物链（分子与分子之间的结构和长度相同）可以与其互补链自组装，也就是说，它们可以形成具有明确的键序列的高度对齐的链双链体。这种聚合物自组装，让人想起DNA自组装，可以产生有价值的生物和非生物材料。挑战在于如何合成这种自组装聚合物。主要研究者提出了一种模板控制的活性聚合来合成自组装聚合物。探索性研究的目标是证明所提出的模板控制活性聚合是可行的，即聚合过程中单体可以保留在模板上，并且聚合可以沿着模板保持。本研究的具体目标如下：1）合成模板和单体。2）开发这些单体的活性聚合工艺。3）开发模板控制的活性聚合工艺。本研究将阐明模板控制的活性聚合的两个主要问题。这项跨学科研究结合了高分子科学、超分子化学、生物化学、热力学和材料工程的要素，将增强我们对大分子在何种程度上必须均匀才能自组装而不是随机自缔合的基本理解。这种理解将成为未来聚合物自组装研究的基础。除了建立知识库和播种未来的研究之外，拟议的项目还可以产生新型功能材料，例如具有卓越机械和热性能的新型丝状材料。