Roswell Park Summer Research Experiences for Undergraduates (REU)

罗斯威尔公园癌症研究所的NSF REU项目为高年级理科专业的学生提供预科暑期研究经验。NSF REU项目的智力价值在于，它为学生提供了将“书本知识”应用于积极的科学方法的机会。这种对科学生活方式的沉浸促进了在做中学习，并进一步刺激了他们对科学高级学位的追求。最终的结果是，我们希望发展一批更多样化的年轻科学家，进入基础科学事业。学生将参加一个具有挑战性的为期十周的课程，重点是基础分子和细胞生物学领域。向REU学生提供的具体研究课题包括：热带非洲爪哇肾素基因的鉴定和鉴定-Kenneth Gross教授在转化生长因子β介导的肌动蛋白重塑和细胞迁移中的作用--John Cowell教授对p53基因蛋白的相互作用--抗人类白细胞抗原-DR单抗H2-27诱导的Gokul Das反应--Soldano Feronne教授对SLP-76和其他酪氨酸激酶在细胞生长中的信号转导的研究--Adam Karpfone组蛋白脱乙酰酶和p300乙酰基酶教授--Michael Brattainn教授通过定义不同表位的不同抗endoglin单抗抑制细胞生长--Ben Seon教授。细胞系来源的树突状细胞中的抗原处理机制--梅尔-韦茨勒教授--苏莫化转录后修饰对SP1依赖转录的调控--玛丽-斯宾格勒教授--用流式细胞术监测淋巴细胞亚群的增殖使用近红外跟踪染料ptir275-Paul Wallace教授高温对死亡配体表达和功能的影响-程志荣教授将继续努力招募公认的代表不足群体的成员，以及来自非研究型大学和学院的女性和学生。RPCI在招收这样的学生方面取得了成功。在过去三年中，68%的参与者来自国家科学基金会公认的代表性不足的群体，所有参与者中有76%是女性。资深教员，他们都有同行评议的支持，指导暑期学员。参与者沉浸在丰富的研究环境中，从事前沿研究，参与科学生活方式。在导师的实验室里，每个学生都被分配了自己的研究项目。这项为期十周的努力的高潮是学生们向他们的同龄人和研究所的科学教职员工做口头海报演示。其他暑期体验包括参加我们杰出的系列讲座、职业咨询会议和周末社交活动。欲了解更多信息，请访问http://www.roswellpark.org/reu/Or联系阿瑟·米哈莱克博士，电子邮件：arthur.michalek@roswellpark.org

The NSF REU Program at the Roswell Park Cancer Institute presents upper division science majors with pre-graduate school summer research experiences. The intellectual merit of the NSF REU program is that it provides students the opportunity to apply "book knowledge" to the active scientific method. This immersion in the scientific lifestyle promotes learning by doing and serves as a further stimulus to maintain their pursuit of advanced degrees in science. The end result is our hopes for the development of a more diverse population of young scientists entering the basic science careers. Students will participate in a challenging ten-week program focused in the area of fundamental molecular and cell biology. Specific research topics offered to REU students would include the following:Identification and characterization of the rennin gene in Xenopus tropicalis - Prof. Kenneth GrossRole of SGK1 and PMEPA1 in TGFbeta-mediated actin remodeling and cell migration - Prof. John CowellInteractions of the p53 genetic protein - Prof. Gokul DasResponses induced by anti-HLA-DR monoclonal antibody H2-27 - Prof. Soldano FeronneStudy of SLP-76 and other tyrosine kinase signaling in cell lines - Prof. Adam KarpfHistone deacetylases and p300 acetylase in cell growth - Prof. Michael BrattainSuppression of cell growth by different anti-endoglin monoclonal antibodies defining different epitopes - Prof. Ben SeonExpression of the antigen processing machinery in cell line derived dendritic-like cells - Prof. Meir WetzlerThe regulation of sp1-dependent transcription by the post-transcriptional modification of sumoylation - Prof. Mary SpenglerMonitoring lymphocyte subset proliferation by flow cytometry, using the near infra red tracking dye, ptir275 - Prof. Paul WallaceThe effects of hyperthermia on expression and function of death ligands - Prof. Zhinrong ChengSpecial efforts will continue to be made to recruit members of recognized under-represented groups, as well as females and students from non-research universities and colleges. The RPCI has been successful in recruiting such students. In the past three years 68% of the participants have been from NSF recognized under-represented groups and 76% of all participants have been female. Senior faculty, all of whom have peer reviewed support, mentor summer participants. Participants are immersed in a rich research environment where they work on cutting-edge research and participate in the scientific lifestyle. Each student is assigned their own research project within their mentor's laboratory. The culmination of this ten-week endeavor is the students' oral poster presentations to their peers and Institute scientific faculty. Other summer experiences include attendance at our distinguished lecture series, career counseling sessions, and weekend social activities. For more information, visit http://www.roswellpark.org/reu/Or contact Dr. Arthur Michalek at arthur.michalek@roswellpark.org or 716-845-2339.