Ring Closing Metathesis of Enynes-Mechanistic Study and Application

本研究的重点包括五个目标：第一，开发一个通用的、高效的发动机环闭合元（RCM）平台，用于范围和机制的研究。其次，定义控制环闭合的参数以及所产生的二烯的E/Z选择性。第三，研究动力RCM的机制。第四，通过炔RCM生成新的钌配合物。第五，将RCM方法应用于抗癌抗生素C-1027的推定9元环核的合成。通过这个奖项，有机和大分子化学项目支持了威斯康星大学麦迪逊分校化学系Daesung Lee博士的研究。李教授将致力于开发一种新的方法，利用炔的闭合环复分解形成大环（大碳环）。该项目将采用机械和合成两种方法，该方法将用于制备具有有趣生物学特性的化合物。该项目有可能对制药业产生更广泛的影响，并将成为研究生的良好培训基地。

The focus of this research involves five goals: First, to develop a general and efficient enyne ring-closing metathesis (RCM) platform for scope and mechanistic studies. Second, to define the parameters that control the ring closure as well as the E/Z selectivity of the resulting dienes. Third, to study the mechanism of the enyne RCM. Fourth, to generate new ruthenium complexes via the enyne RCM. Fifth, to to apply the RCM methodology to the synthesis of putative 9-membered ring cores of the anticancer antibiotic C-1027. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Daesung Lee in the Department of Chemistry at the University of Wisconsin, Madison. Professor Lee will focus his work on the development of a new process for the formation of macrocycles (large carbon rings) using the ring-closing metathesis of enynes. Both mechanistic and synthetic approaches will be followed in the project and the methodology will be used to prepare compounds with interesting biological properties. The project has potential for broader impact in the pharmaceutical industry and will serve as an excellent training ground for graduate students.