NIRT: Nanohybrids and Nanobiohybrids, Bottom-Up Approach to Nanopatterned Surface Arrays and Application

NIRT：纳米杂化物和纳米生物杂化物，纳米图案表面阵列的自下而上方法及其应用

• 批准号: 0404195
• 负责人: Ulrich Wiesner
• 金额: --
• 依托单位: Cornell University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0404195&HistoricalAwards=false
• 关键词: NIRT; Nanohybrids; Nanobiohybrids; Bottom; Up

This Nanoscale Interdisciplinary Research Team (NIRT), cofunded by the Division of Materials Research, the Division of Chemical and Transport Systems, and the Division of Engineering Education and Centers, will develop a "bottom-up" approach based on block copolymer directed thin film assembly of silica nanostructures on silicon and subsequent laser induced melting to generate silicon surface arrays with spacings down to the molecular level (~10 nm). The aim is to understand the dynamics governing creation of these structures, as well as to invent enabling technologies that will allow inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. In a first application we will engineer the surfaces towards integration of biomolecules, i.e., to match the natural spacing of an antibody. The team consists of B. Baird, D. Muller, S. Gruner, C. Ober (collaborator), M. Thompson, and U. Wiesner. This work falls into the NSF research and education themes "Nanoscale Structures, Novel Phenomena, and Quantum Control" and (to a lesser extend) "Nanoscale Devices and System Architecture". Intellectual merit of the proposed activityUnderstanding nanostructured thin film formation and nanopillar array formation including the effects of surface wetting and crystal growth in small dimensions will have impact on many areas of nanotechnology. If successful we will enable technologies for the inexpensive fabrication of large areas of such nanostructures without the use of traditional photolithography. This will open up the field to many which currently don't have access to such expensive facilities. Furthermore, engineering the surface structure of a synthetic material towards the molecular architecture of a biomolecule constitutes a powerful paradigm for nanobiotechnology and may lead to completely novel ways of organizing, e.g., proteins on solid substrates for analysis and detection. Cornell is uniquely positioned to make advances in this field and the program will make effective use of Cornell facilities such as the Cornell High Energy Synchrotron Source (CHESS) as well as facilities of the Cornell Center for Materials Research (CCMR) and the Nanobiotechnology Center (NBTC).Broader impacts resulting from the proposed activity Through the collaborative environment with activities ranging from organic synthesis to materials characterization to biology we will promote a way of teaching, training, and learning and thus a unique educational experience for postdoctoral researchers, graduate and undergraduate students not frequently obtained. We will also involve other components of training and development of human resources including the participation of underrepresented groups, efforts to enhance the infrastructure for research and education, and industrial outreach. To this end we intend to work with the excellent and proven platforms provided by the NSF funded Cornell Center for Materials Research (CCMR) and Nanobiotechnology Center (NBTC). In particular, because of the large multiplication effect we will develop Teacher Teaching Teacher (T3) workshops with hands-on lessons that can be brought back into the classrooms, and we will build on a successful collaboration with Simmons College, a primary female college, to introduce students to concepts of nanoscale science and engineering.

这个纳米级跨学科研究小组（NIRT），由材料研究部，化学和运输系统部以及工程教育和中心部共同资助，将开发一种“自下而上”的方法，该方法基于嵌段共聚物指导的二氧化硅纳米结构在硅上的薄膜组装和随后的激光诱导熔融，以产生间距低至分子水平的硅表面阵列（~ 10 nm）。其目的是了解这些结构的动态管理创建，以及发明使能技术，将允许廉价制造大面积的这种纳米结构，而不使用传统的光刻。在第一个应用中，我们将设计表面以整合生物分子，即，以匹配抗体的自然间隔。这个队由B组成。Baird，D.穆勒，S。格鲁纳角Ober（collaborator），M. Thompson和U.威斯纳这项工作福尔斯属于NSF的研究和教育主题“纳米结构，新现象和量子控制”和（在较小程度上）“纳米器件和系统架构”。建议的activityUnderstanding纳米结构薄膜的形成和纳米柱阵列的形成，包括在小尺寸的表面润湿和晶体生长的影响，将对纳米技术的许多领域产生影响。如果成功的话，我们将能够在不使用传统光刻法的情况下廉价制造大面积这种纳米结构的技术。这将为许多目前无法使用如此昂贵的设施的人打开这一领域。此外，将合成材料的表面结构设计成生物分子的分子结构构成了纳米生物技术的强大范例，并可能导致完全新颖的组织方式，例如，用于分析和检测的固体基质上的蛋白质。康奈尔大学在这一领域取得进展的独特地位，该计划将有效利用康奈尔大学的设施，如康奈尔大学高能同步加速器源（CHESS）以及康奈尔大学材料研究中心（CCMR）和纳米生物技术中心（NBTC）的设施。通过与从有机合成到材料特性鉴定等活动的协作环境，对于生物学，我们将促进一种教学，培训和学习的方式，从而为博士后研究人员，研究生和本科生提供独特的教育经验。我们还将涉及人力资源培训和开发的其他组成部分，包括代表性不足的群体的参与，努力加强研究和教育的基础设施，以及工业推广。为此，我们打算与NSF资助的康奈尔材料研究中心（CCMR）和纳米生物技术中心（NBTC）提供的优秀和成熟的平台合作。特别是，由于大的乘法效应，我们将开发教师教学教师（T3）工作坊，可以带回课堂的实践经验，我们将建立在与西蒙斯学院，一个主要的女大学的成功合作，向学生介绍纳米科学和工程的概念。