NIRT: Titanium-Based Biomolecular Manipulation Tools

提案编号： CTS-0404444主要制造商：Carl Meinhartin机构： 加州大学圣巴巴拉分校：钛基生物分子操纵工具该提案是响应纳米科学与工程倡议，NSF 03-043，类别NIRT。 新型微/纳流控芯片将被开发和优化，用于分离、混合、浓缩和定位生物分子和细胞。 将开发具有交流电动力学微流体的钛微/纳米纤维技术的开创性工作，为生物技术行业提供独特的工具。 钛是一种相对较新的制造纳米结构的平台。 它允许制造复杂的3-D电极结构，并且是生物相容的。 将对电动现象进行理论和实验分析，以研究潜在物理学的细节。 钛制造技术有可能彻底改变微/纳米器件，特别是在生物技术，药物输送和体内传感探测领域，其中耐用性和生物相容性至关重要。先进的电动力学和纳米级电极结构可用于浓缩小（~50 nm）蛋白质和病毒颗粒，这在以前使用介电电泳无法实现。 这个研究项目将提供一个机会，教育研究生在微/纳米制造，纳米流体，电动力学和微/纳米器件细胞培养领域。 PI教授MEMS/NEMS设计制造，微/纳米流体电动力学的高级/研究生水平的新开发的三门课程序列。这些课程让学生广泛接触到基本问题和MEMS/NEMS的最新技术，并培养学生在纳米技术的职业和研究机会。 该研究计划还将用于推进科学和工程领域代表性不足的群体。 此外，PI将继续在当地高中开展外展活动，教育学生和教师科学和技术如何影响社会，并鼓励学生从事纳米技术科学的职业。

PROPOSAL NO.: CTS-0404444PRINCIPAL INVESTIGATOR: CARL MEINHARTINSTITUTION: UNIVERSITY OF CALIFORNIA- SANTA BARBARANIRT: TITANIUM-BASED BIOMOLECULAR MANIPULATION TOOLS This proposal was received in response to Nanoscale Science and Engineering initiative, NSF 03-043, category NIRT. Novel micro/nanofluidic chips will be develop and optimized for separating, mixing, concentrating and positioning biomolecules and cells. Pioneering work in titanium micro/nanofabrication technology with alternating current electrokinetics & microfluidics will be developed to provide unique tools for the biotechnology industry. Titanium is a relatively new platform for fabrication of nanostructures. It allows complicated 3-D electrode structures to be fabricated, and is biologically compatible. Theoretical and experimental analysis of electrokinetic phenomena will be conducted to investigate details of the underlying physics. The titanium fabrication technology has the potential to revolutionize micro/nanoscale devices, especially in the areas of biotechnology, drug delivery, and in vivo sensing & probing, where durability and bio-compatibility are critical. The advanced electrokinetics and nanoscale electrode structures can be used to concentrate small (~50 nm) proteins and viral particles, which has not been achievable previously using dielectrophoresis. This research project will provide an opportunity to educate graduate students in the areas of micro/nano fabrication, nanofluidics, electrokinetics, and cell culturing in micro/nanodevices. The PIs teach a newly-developed three course sequence at the senior/graduate level on MEMS/NEMS design & fabrication, micro/nanofluidics & electrokinetics. These courses give students broad exposure to fundamental issues and the current state of the art in MEMS/NEMS and train students for careers and research opportunities in nanotechnology. The research program will also be used to advance underrepresented groups in science and engineering. In addition, the PIs will continue their outreach activities at local high schools, educating students and teachers about how science and technology impacts society, and encouraging students to pursue careers in nanotechnology & science.