Chemistry of High-Energy Content Reagents

高能试剂化学

• 批准号: 0405276
• 负责人: Gary Schuster
• 金额: $ 49.6万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0405276&HistoricalAwards=false
• 关键词: Chemistry; Energy; Content; Reagents

With this accomplishment based renewal award, the Organic and Macromolecular Chemistry Program continues its support for the work of Professor Gary B. Schuster of the Department of Chemistry and Biochemistry at the Georgia Institute of Technology in Atlanta, GA. The research will continue the PI's investigations of the factors affecting charge transport in DNA. The general approach will be to place an electron donor on a DNA chain, photogenerate a radical cation, migrate the charge along the chain, and trap the charge with a stronger electron donor. Various factors influencing the rate of this process will be evaluated. In particular, the role of the DNA counterions in charge migration, the effect of proton transfers on the process, and the role of water in charge transport will be probed using this technique. In order to assess the relevance of these experiments with soluble DNA to oxidative damage in genomic DNA, charge migration in DNA condensates will be investigated.These studies are expected to have broad impact upon the biological sciences. In particular, they will contribute to our knowledge of factors responsible for DNA damage and repair mechanisms and their potential relationship to genetic mutations. In addition the research will provide broad interdisciplinary training for students in areas ranging from nucleic acid chemistry to nanosecond spectroscopy.

有了这个基于成就的更新奖，有机和大分子化学项目继续支持乔治亚州亚特兰大理工学院化学和生物化学系的Gary B. Schuster教授的工作。这项研究将继续PI对DNA中影响电荷传输因素的调查。一般的方法是在DNA链上放置一个电子供体，光产生一个自由基阳离子，沿着链迁移电荷，并用一个更强的电子供体捕获电荷。将评价影响这一过程速率的各种因素。特别是，DNA反离子在电荷迁移中的作用，质子转移对这一过程的影响，以及水在电荷传输中的作用将使用这种技术进行探讨。为了评估这些可溶DNA实验与基因组DNA氧化损伤的相关性，将研究DNA凝聚物中的电荷迁移。这些研究有望对生物科学产生广泛的影响。特别是，它们将有助于我们了解导致DNA损伤和修复机制的因素以及它们与基因突变的潜在关系。此外，该研究将为学生提供从核酸化学到纳秒光谱学等领域的广泛跨学科培训。