US-India Cooperative Research: Synthesis and Study of Interactions of Organic Ligands with Various DNA Structures Through Spectroscopic and DNA Sequencing Techniques

美印合作研究：通过光谱和DNA测序技术合成和研究有机配体与各种DNA结构的相互作用

• 批准号: 0080391
• 负责人: Gary Schuster
• 金额: $ 2.72万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0080391&HistoricalAwards=false
• 关键词: US; India; Cooperative; Research; Synthesis

0080391SchusterDescription: This award is for US-India Cooperative Research: Synthesis and Study of Interactions of Organic Ligands with Various DNA Structures through Spectroscopic and DNA Sequencing Techniques. Professor Gary Schuster of the Georgia Institute of Technology and Indian collaborator Danaboyina Ramaiah of the Regional Research Laboratory (CSIR), Trivandrum will conduct experimental research on the synthesis of a variety of acridine, quinone and perylene derivatives and their interactions with select DNA structures such as hairpins, base bulges, triplexes and G-quadruplexes. These studies are expected to provide greater understanding of DNA structures, structure-property relationships and develop effective molecular probes for the recognition of nucleic acid structures.Scope: The Georgia Tech group is well regarded for its expertise in photochemical and spectroscopic studies of organic compounds, particularly for interactions of photochemically active compounds with DNA. The photochemistry center in Trivandrum is highly regarded and among the most productive research centers in India. This collaboration uses the strengths of both groups to further the understanding of DNA photo-cleavage reactions. The project is based on a significant collection of preliminary results obtained at Trivandrum and is likely to lead to advances in fundamental knowledge. It may also lead to practical biological and health-related applications in the future. This award is supported jointly with the Government of India's Department of Science and Technology.

0080391舒斯特描述：该奖项是美国-印度合作研究：通过光谱和DNA测序技术合成和研究有机配体与各种DNA结构的相互作用。 格鲁吉亚理工学院的加里舒斯特教授和特里万德伦区域研究实验室（CSIR）的印度合作者Danaboyina Ramaiah将对各种吖啶、醌和二萘嵌苯衍生物的合成及其与选定的DNA结构（如发夹、碱基凸起、三链体和G-四链体）的相互作用进行实验研究。 这些研究预计将提供更好的理解DNA的结构，结构与性能的关系，并开发有效的分子探针识别核酸structure.Scope：该格鲁吉亚技术组是公认的专业知识，在光化学和光谱研究的有机化合物，特别是光化学活性化合物与DNA的相互作用。 特里凡得琅的光化学中心备受推崇，是印度最具生产力的研究中心之一。 这项合作利用了两个小组的优势，以进一步了解DNA光切割反应。 该项目是基于在特里凡得琅获得的大量初步成果，并有可能导致基础知识的进步。它还可能导致未来实际的生物和健康相关应用。 该奖项是与印度政府科学技术部共同支持的。